首页|期刊导航|Bone Research|Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways

Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways

Hui Li Xiaofeng Jiang Yongbing Xiao Yuqing Zhang Weiya Zhang Michael Doherty Jacquelyn Nestor Changjun Li Jing Ye Tingting Sha Houchen Lyu Jie Wei Chao Zeng Guanghua Lei

Bone Research2023，Vol.11Issue(4)：P.834-846,13.

Bone Research2023，Vol.11Issue(4)：P.834-846,13.DOI:10.1038/s41413-023-00292-7

Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways

Hui Li ¹Xiaofeng Jiang ¹Yongbing Xiao ¹Yuqing Zhang ²Weiya Zhang ³Michael Doherty ³Jacquelyn Nestor ⁴Changjun Li ⁵Jing Ye ¹Tingting Sha ⁶Houchen Lyu ⁷Jie Wei ⁸Chao Zeng ⁹Guanghua Lei⁹

作者信息

1. Department of Orthopaedics,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China Hunan Key Laboratory of Joint Degeneration and Injury,Changsha 410008 Hunan,China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,China
2. Division of Rheumatology,Allergy,and Immunology,Department of Medicine,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02115,USA The Mongan Institute,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02115,USA
3. Academic Rheumatology,School of Medicine,University of Nottingham,Nottingham NG51PB,UK Pain Centre Versus Arthritis UK,Nottingham NG51PB,UK
4. Division of Rheumatology,Allergy,and Immunology,Department of Medicine,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02115,USA
5. Hunan Key Laboratory of Joint Degeneration and Injury,Changsha 410008 Hunan,China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,China Department of Endocrinology,Endocrinology Research Center,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China
6. Hunan Key Laboratory of Joint Degeneration and Injury,Changsha 410008 Hunan,China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,China
7. Department of Orthopaedics,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China
8. Department of Orthopaedics,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,China Health Management Center,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China Department of Epidemiology and Health Statistics,Xiangya School of Public Health,Central South University,Changsha 410008 Hunan,China
9. Department of Orthopaedics,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China Hunan Key Laboratory of Joint Degeneration and Injury,Changsha 410008 Hunan,China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,China National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008 Hunan,China
折叠

摘要

关键词

osteoarthritis/subpopulations/elevated

分类

医药卫生

引用本文复制引用

Hui Li,Xiaofeng Jiang,Yongbing Xiao,Yuqing Zhang,Weiya Zhang,Michael Doherty,Jacquelyn Nestor,Changjun Li,Jing Ye,Tingting Sha,Houchen Lyu,Jie Wei,Chao Zeng,Guanghua Lei..Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways[J].Bone Research,2023,11(4):P.834-846,13.

基金项目

supported by the National Natural Science Foundation of China(81930071,82072502) （81930071,82072502）

the National Natural Science Foundation Regional Innovation and Development Joint Fund(U21A20352) （U21A20352）

the National Key Research and Development Project(2022YFC3601900,2022YFC2505500) （2022YFC3601900,2022YFC2505500）

the Project Program of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital,2021LNJJ06,2022LNJJ07) （Xiangya Hospital,2021LNJJ06,2022LNJJ07）

the Natural Science Foundation of Hunan Province(2022JJ20100) （2022JJ20100）

the Key Research and Development Program of Hunan Province(2021SK2017) （2021SK2017）

the Science and Technology Innovation Program of Hunan Province(2022RC3075) （2022RC3075）

the Central South University Innovation-Driven Research Program(2023CXQD031)。（2023CXQD031）

Bone Research

OACSCDMEDLINE

ISSN：2095-4700

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