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聚吡咯导电水凝胶的制备及在生物医学领域中的应用进展OA北大核心CSTPCD

Preparation and Application of Polypyrrole Conductive Hydrogels in Biomedical Field

中文摘要英文摘要

水凝胶是一类具有含水率高、生物相容性良好和类细胞外基质等特点的材料,其中,聚吡咯(PPy)导电水凝胶兼具水凝胶本身三维多孔结构与高含水率等物理特性和优异的导电性,可用于检测生物系统产生的电信号以及提供电刺激,调节细胞与组织的活动和功能,广泛应用于生物医学领域.本文对PPy导电水凝胶在生物医学领域的最新研究进展进行了评述.根据PPy与水凝胶基质结合的交联机理,将其分为非共价交联型PPy导电水凝胶与共价交联型PPy导电水凝胶,重点介绍了PPy导电水凝胶在生物医学领域(皮肤损伤修复、神经修复、心肌修复以及柔性传感等)中的应用,并讨论了PPy导电水凝胶在生物医学领域中的发展趋势和面临的挑战.

Hydrogel is a kind of material with high water content,good biocompatibility and extracellular matrix-like property,among which polypyrrole(PPy)conductive hydrogels have both physical characteristics and excellent conductivity of hydrogels themselves.Its conductivity can be used to detect electrical signals generated in biological systems and provide electrical stimulation to regulate the activities and functions of cells and tissues.These characteristics make it widely used in the biomedical field.The recent progress of PPy conductive hydrogels in biomedical field was reviewed in this paper.In terms of classification,according to the cross-linking mechanism of PPy and hydrogel matrix,the non-covalent cross-linked PPy conductive hydrogels and covalent cross-linked PPy conductive hydrogels were divided.The applications of PPy conductive hydrogels in the biomedical field(Skin damage repair,nerve repair,myocardial repair and flexible sensing,etc.)were mainly introduced,and the development trend and challenges of PPy conductive hydrogels in the biomedical field were discussed.

任昆宇;付如民;田雨;康新昌;周蕾;谭帼馨

广东工业大学轻工化工学院,广州 510006华南理工大学材料科学与工程学院,国家人体组织功能重建工程技术研究中心,广州 510006广州医科大学附属第三医院脊柱外科,广州 510145

聚吡咯水凝胶导电组织修复柔性传感评述

PolypyrroleHydrogelElectrical conductivityTissue repairFlexible sensingReview

《分析化学》 2024 (001)

骨修复植入体表面力-电响应微环境的构建及其骨整合机制研究

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国家自然科学基金项目(Nos.51932002,U22A20160)、广东省自然科学基金项目(No.2023A1515011039)和广州市科技计划项目(Nos.202102010008,2023A03J0383)资助. Supported by the National Natural Science Foundation of China(Nos.51932002,U22A20160),the Natural Science Foundation of Guangdong Province(No.2023A1515011039)and the Guangzhou Science and Technology Planning Project(Nos.202102010008,2023A03J0383).

10.19756/j.issn.0253-3820.231169

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