军事医学2024，Vol.48Issue(1)：58-62,5.DOI:10.7644/j.issn.1674-9960.2024.01.010
黄病毒属非结构蛋白5的研究进展
Research progress in flavivirus non-structural protein 5
摘要
Abstract
The non-structural protein 5(NS5)is a highly conserved protein in the Flavivirus genus,acting as both a methyltransferase(MTase)and an RNA-dependent RNA polymerase(RdRp).It has been well documented that NS5 plays a crucial role in the replication of viral RNA.Recent studies have shown that NS5 proteins from different flaviviruses interact with various proteins in host cells,aiding the virus in evading the immune system.This review summarizes the structure,subcellular localization,and function of NS5 proteins.Additionally,we outline how flavivirus NS5 proteins contribute to viral replication and immune evasion.Lastly,we present the recent developments of specific small molecule inhibitors that target NS5 proteins.关键词
黄病毒/非结构蛋白5/甲基转移酶/RNA依赖的RNA聚合酶/病毒复制/免疫逃逸/小分子抑制剂Key words
flavivirus/non-structural protein 5/methyltransferase/RNA-dependent RNA polymerase/virus replication/immuneevasion/smallmolecule inhibitor分类
医药卫生引用本文复制引用
秦琳琳,郭东星,李淑莲,杨光..黄病毒属非结构蛋白5的研究进展[J].军事医学,2024,48(1):58-62,5.基金项目
国家自然科学基金项目(81871618) （81871618）
