解放军医学院学报2023，Vol.44Issue(11)：1187-1193,7.DOI:10.12435/j.issn.2095-5227.2023.115
基因编辑技术在军事医学领域的潜在应用
Advances in gene editing technologies and its potential application in military medicine
摘要
Abstract
Gene editing technology is an engineering technology that can perform targeted"editing"of target genes in organisms.It has developed rapidly in recent years and has impacted various fields of life science.It is also the most competitive next-generation core disruptive biotechnology worldwide.Gene editing technology has been applied to many fields such as crop improvement,livestock breeding,treatment of genetic and metabolic diseases,resistance to bacterial and viral infections,drug screening,preparation of new biofuels,and food industry.Gene editing technology also has important military medical uses,for example,the harm and toxicity of pathogens can be increased through gene editing technology.Conservative sequence design drugs and vaccines targeting pathogens can protect against infection by multiple virus strains and variants.By targeting the host,epigenetic gene editing mediated by the CRISPR/dCas9 system does not alter DNA genetic traits,while it can reversibly enhance the body's effectiveness and resistance to biological,chemical,and radiation damage.Targeting the nucleic acid enzyme and guiding RNA of the gene editor itself can accurately regulate the use of gene editing technology and defend against the damage of misuse of gene editing technology and new genetic biological warfare agents.Gene editing technology also has significant advantages in the field of infectious disease diagnosis and treatment,which can completely cure certain types of infectious diseases.关键词
基因编辑技术/基因增强/表观遗传基因编辑/基因编辑调控技术Key words
gene editing technique/gene performance enhancement/epigenetic editing/regulation of gene editing分类
医药卫生引用本文复制引用
王征旭,曹俊霞,王友亮..基因编辑技术在军事医学领域的潜在应用[J].解放军医学院学报,2023,44(11):1187-1193,7.基金项目
2020年后勤理论研究(QT2020A06-B004) （QT2020A06-B004）
2022年国家社会科学基金(2022-SKJJ-B-068) （2022-SKJJ-B-068）
