解放军医学院学报2023，Vol.44Issue(12)：1372-1378,1383,8.DOI:10.12435/j.issn.2095-5227.2023.092
系统免疫炎症营养指数对接受免疫检查点抑制剂治疗的非小细胞肺癌患者临床效果及预后的评估价值研究
Predictive value of systemic immune inflammatory nutritional index for clinical efficacy and prognosis of non-small cell lung cancer patients receiving immune checkpoint inhibitors
石明伟 1王俊康 2王静3
作者信息
- 1. 合肥京东方医院肿瘤内科,安徽合肥 230000
- 2. 解放军联勤保障部队第九四三医院烧伤整形科,甘肃武威 733000
- 3. 解放军总医院第一医学中心全科医学科,北京 100853
- 折叠
摘要
Abstract
Background Immunocheckpoint inhibitors(ICIs)can improve the survival time of patients with non-small cell lung cancer(NSCLC),but there is still a lack of related bioindicator that affect the therapeutic effect and prognosis of immunocheckpoint inhibitors.Objective To explore the predictive value of the clinical effect and prognosis of the new index system immunoinflammatory nutrition index(SIINI)on NSCLC patients treated with ICIs.Methods Clinical data about 126 NSCLC patients in Hefei BOE Hospital from January 2020 to May 2022 were collected,and all patients were treated with immunopharmaceuticals.Multivariate logistic regression analysis was used to analyze the influencing factors of disease control rate(DCR)of NSCLC patients treated with ICIs,and Cox regression analysis was applied to analyze the influencing factors of disease progression free survival(PFS)in NSCLC patients receiving ICIs treatment.Results The objective response rate(ORR)and DCR of 126 NSCLC patients after treatment were 27.78％and 73.02％,respectively.Logistic regression results showed that NSCLC patients with TNM stage at ⅢB-ⅢC(OR=0.449,95％CI:0.224-0.898),the number of metastatic sites less than 3(OR=0.345,95％CI:0.122-0.970),NLR≤2.61(OR=0.244,95％CI:0.089-0.670),and SIINI≤95.34(OR=0.284,95％CI:0.107-0.751)had better efficacy(P＜0.05).Cox regression results showed that age≥60 years old(HR=1.811,95％CI:1.073-3.059),TNM stage Ⅳ(HR=2.364,95％CI:1.253-4.458),and SIINI>95.34(HR=1.543,95％CI:1.037-3.407)were risk factors for PFS in NSCLC patients receiving ICIs treatment(P＜0.05).Conclusion SIINI may be an independent influencing factor for DCR in patients with NSCLC treated with ICIs,and may be used as a predictor of the efficacy and prognosis of immunotherapy for patients with NSCLC.关键词
非小细胞肺癌/免疫检查点抑制剂/系统免疫炎症营养指数/疗效/预后Key words
non-small cell lung cancer/immune checkpoint inhibitors/systemic immune inflammation nutritional index/clinical efficacy/prognosis分类
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石明伟,王俊康,王静..系统免疫炎症营养指数对接受免疫检查点抑制剂治疗的非小细胞肺癌患者临床效果及预后的评估价值研究[J].解放军医学院学报,2023,44(12):1372-1378,1383,8.
