解放军医学院学报2023，Vol.44Issue(12)：1403-1409,7.DOI:10.12435/j.issn.2095-5227.2023.110
脑-肠-微生物轴在肠易激综合征发病中的研究进展
Research advances in brain-gut-microbiome axis in pathogenesis of irritable bowel syndrome
摘要
Abstract
In recent years,it has been found that gut microbiota is a key regulator of brain-gut axis signal transduction,which can affect neuronal,endocrine,metabolic,and immune pathways through several mechanisms,thus promoting the continuous bidirectional communication between the gut and the brain,which is defined as the brain-gut axis.At present,it is considered that the brain-gut-microbiome axis is related to the occurrence of many diseases,and the regulation of brain-gut-microbiome axis can provide new research ideas for disease treatment.Irritable bowel syndrome is a common chronic functional disease,its pathophysiological mechanism has not been fully revealed,and there is no effective treatment.Fecal microbiota transplantation is the transplantation of fecal bacteria from healthy individuals to recipients.The essence is to treat disease by regulating the brain-gut-microbiome axis.It is currently a hot topic in the treatment of IBS.This article mainly reviews the influence of gut microbiota,brain-gut-microbiome axis disorder on the pathogenesis of IBS,and the new research progress of FMT,aiming to provide ideas for clinical researchers.关键词
肠道微生物群/脑-肠-微生物轴/治疗/肠易激综合征/粪菌移植Key words
gut microbiota/brain-gut-microbiome axis/treatment/irritable bowel syndrome/fecal microbiota transplantation分类
医药卫生引用本文复制引用
李嘉辉,林强,梁世洋,宋俊良,王景杰..脑-肠-微生物轴在肠易激综合征发病中的研究进展[J].解放军医学院学报,2023,44(12):1403-1409,7.基金项目
国家自然科学基金面上项目(81770534) （81770534）
