解放军医学院学报2023，Vol.44Issue(12)：1410-1414,5.DOI:10.12435/j.issn.2095-5227.2023.109
基于cGAS/STING信号通路的肿瘤治疗研究进展
Research advances in tumor treatment based on cGAS/STING signaling pathway
摘要
Abstract
Innate immunity is the body's first line of defense against disease.In recent years,a series of studies have shown that the cGAS/STING signaling pathway,an important component of host innate immunity,may play an important role in anti-tumor immunity.cGAS is an innate immune sensor that can recognize abnormal dsDNA in the cytoplasm and activate the STING protein by catalyzing the formation of the second messenger cGAMP,thereby promoting the release of type I interferon.The produced type I interferon can effectively connect innate immunity and adaptive immunity by promoting the maturation and migration of dendritic cells and enhancing the cytotoxic effect of T lymphocytes or natural killer cells.The cGAS/STING signaling pathway has been confirmed to have anti-tumor effects as well as tumor-promoting effects in the occurrence and progression of tumors.With the entry of STING agonists into clinical trials,their combined application with various treatment methods has also been widely studied.At the same time,nano-drug loading systems have also been developed to achieve stronger anti-tumor effects of STING agonists.This article will review the mechanism of tumor regulation and its application in immunotherapy,so as to provide reference for the development of immunotherapy targeting this pathway.关键词
cGAS-STING信号通路/抗肿瘤作用/纳米材料/免疫治疗Key words
CGAS-STING pathway/antitumor effect/nanomaterials/immunotherapy分类
医药卫生引用本文复制引用
何丽婷,罗婷,于杰,梁萍..基于cGAS/STING信号通路的肿瘤治疗研究进展[J].解放军医学院学报,2023,44(12):1410-1414,5.基金项目
国家自然科学基金项目(92159305) （92159305）
