天津工业大学学报2023，Vol.42Issue(6)：17-23,7.DOI:10.3969/j.issn.1671-024x.2023.06.003
交联PMMA@玻尿酸微胶囊的制备及其释放性能
Preparation and release properties of crosslinked PMMA@hyaluronic acid microcapsules
摘要
Abstract
In order to prepare hyaluronic acid microcopsule,microcapsules with hyaluronic acid aqueous solution as the core and pentaerythritol tetraacrylate(PET4A)cross-linked methyl methacrylate(MMA)polymer as the wall were prepared by a free radical polymerization in a W/O inverse emulsion system.The morphology,structure,particle size distribution,coating ratio and release property of the microcapsules were characterized by scanning electron microscopy(SEM),transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FTIR),laser scattering particle size distribution analyzer(LSPSDA)and ultraviolet spectrophotometer(UV).The results showed that the microcapsules had irregular spherical shape and core-shell structure.When the oil/water ratio was 10∶1,the core/wall ratio was 1∶1,the dosage of hyaluronic acid was 1.5 mg/mL,and the addition of crosslinking agent was 0.67％(relative to the wall material),the encapsulation efficiency and drug loading rate of the microcapsules reached the maximum of 81.40％and 1.221％,respectively.The surface morphology was the best,and the particle size was within 1.4-2.0 μm.The cumulative release of microcapsules decreased with the increase of the amount of crosslinking agent.At the same time,the microcapsules were pH-responsive,and the cumulative release was the most when pH=5.5.关键词
W/O反相乳液/玻尿酸/季戊四醇四丙烯酸酯/甲基丙烯酸甲酯/微胶囊/释放性能/自由基聚合Key words
W/O inverse emulsion/hyaluronic acid/pentaerythritol tetraacrylate/methyl methacrylate/microcapsule/re-lease property/free radical polymerization分类
通用工业技术引用本文复制引用
王建平,王凡,王喜睿,王学晨,李伟,张兴祥..交联PMMA@玻尿酸微胶囊的制备及其释放性能[J].天津工业大学学报,2023,42(6):17-23,7.基金项目
国家自然科学基金资助项目(51573135) （51573135）
