武警医学2024，Vol.35Issue(2)：121-124,129,5.
黑地雷方联合艾瑞昔布治疗风湿热痹型骨关节炎的疗效
Clinical effect of Heidilei Decoction combined with imrecoxib on osteoarthritis with wind dampness heat Bi syndrome
黄楠 1张军 1武永刚 1郭浩 1余磊 1梁宏伟 1赵宝峰1
作者信息
摘要
Abstract
Objective To evaluate the clinical efficacy of of Heidilei Decoction combined with imrecoxib(CHDI)on osteoar-thritis with wind dampness heat Bi syndrome(OA-WDHB)and its effect on matrix metalloproteinases(MMPs)and tissue inhibitor of matrix metalloproteinases(TIMPs)expression.Methods A total of 63 OA-WDHB patients who attended the Beijing Municipal Corps Hospital of Chinese People's Armed Police Force from April 2021 to April 2023 were selected,and randomly divided into control group(treated with imrecoxib,n=31)and combined drugs group(treated with CHDI,n=32).After 4 weeks of treatment,the pain visual analogue scale(VAS),Western Ontario and McMaster Universities osteoarthritis index(WOMAC)and Lequesne algofunctional index(LAI)in knee joints of patients were evaluated,the improvement rate of clinical efficacy was calculated,and the MMP-9 and TIMP-1 expression and MMP-9/TIMP-1 in serum were detected.The adverse reactions of the two groups during the treatment and dis-ease recurrence within 6 months of follow-up were monitored.Results The clinical efficacy rate in CHDI group(90.6％)were notably elevated as compared to the control group(80.6％)(P<0.05).The VAS,WOMAC,LAI,serum MMP-9 and TIMP-1 expression and MMP-9/TIMP-1 in post-treatment of both groups were evidently improved as compared to those in pre-treatment(P<0.05 or P<0.01).In comparison with the control group,the VAS,WOMAC,LAI,serum MMP-9 and TIMP-1 expression and MMP-9/TIMP-1 were significantly improved in CHDI group after the treatment(P<0.01).The incidence of adverse reactions in CHDI group was 12.4％,which was not statistically significant when compared with 9.6％in the control group(P>0.05).The recurrence rate in CH-DI group was 10.3％during the follow-up,which was significantly lower than that in the control group,which was 32.0％(P<0.05).Conclusions The efficacy of CHDI in improving the OA-WDHB symptoms and reducing the disease recurrence rate may be related to its ability to modulate the dynamic balance of MMPs and their inhibitors,TIMPs.关键词
骨关节炎/风湿热痹/黑地雷方/基质金属蛋白酶9/组织金属蛋白酶抑制因子1Key words
osteoarthritis/wind dampness heat Bi syndrome/Heidilei Decoction/matrix metalloproteinase-9/tissue inhibitor of matrix metalloproteinases-1分类
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黄楠,张军,武永刚,郭浩,余磊,梁宏伟,赵宝峰..黑地雷方联合艾瑞昔布治疗风湿热痹型骨关节炎的疗效[J].武警医学,2024,35(2):121-124,129,5.
