壳聚糖抗菌成膜喷剂在鼻咽癌患者PICC所致接触性皮炎治疗中的应用效果OACSTPCD

Objective To investigate the application effect of chitosan antibacterial film-forming spray in the treatment of PICC contact dermatitis in patients with nasopharyngeal carcinoma.Methods A total of 94 patients with nasopharyngeal carcinoma and PICC-induced contact dermatitis in the 909th Hospital of PLA Joint Logistics Support Force from May 2020 to April 2022 were selected as intervention subjects.According to time nodes,46 patients from May 2020 to April 2021 were selected as control group,and 48 pa-tients from May 2021 to April 2022 were selected as observation group.The control group was given dexamethasone injection external coating combined with 3M transparent dressing for PICC dressing change,while the observation group was given chitosan antibacterial film forming spray combined with 3M transparent dressing for PICC dressing change.The clinical efficacy,incidence of complications,healing time,times of dressing change,out-of-pocket costs and satisfaction of patients in the two groups were compared.Results The total effective rate(95.83％,100％)in the first and second weeks of treatment in the observation group was significantly higher than that in the control group(73.91％,89.13％)(P<0.05).Healing time[(10.43±0.52)d]and dressing change times(3.30±0.69)in observation group were significantly lower than those in control group[(18.15±0.33)d;(5.67±0.96)](P<0.05).The satisfaction score of observation group(8.71±0.82)was significantly higher than that of control group(5.67±0.96)(P<0.05),and there was no significant difference in catheter displacement rate,catheter removal rate or out-of-pocket costs between the two groups(P>0.05).Conclusions Chitosan antibacterial film spray is effective in the treatment of PICC catheterization contact dermatitis in patients with nasopharyngeal carcinoma with concurrent radiotherapy and chemotherapy,which can reduce the number of dressing chan-ges,reduce nursing workload,reduce local infection rate and improve patient satisfaction.