外科理论与实践2023，Vol.28Issue(6)：529-535,7.DOI:10.16139/j.1007-9610.2023.06.08
乳头状甲状腺微小癌不宜作为术后131I治疗的决策依据
Papillary thyroid microcarcinoma should not be used as the basis for postoperative 131I therapy
蔡晓雨 1张瑞国 2胡玉敬 1王任飞 3边艳珠1
作者信息
- 1. 河北省人民医院核医学科,河北 石家庄 050000
- 2. 天津医科大学总医院核医学科,天津 300154
- 3. 上海市第十人民医院核医学科,上海 200072
- 折叠
摘要
Abstract
Objective To analyze the clinicopathological data of patients with papillary thyroid microcarcinoma(PTMC)and papillary thyroid non-microcarcinoma(non-PTMC)who received 131I therapy retrospectively,and compare the therapeutic response of the two groups of patients,so as to guide 131I therapy decisions for PTMC patients.Methods A total of 1 118 patients with papillary thyroid carcinoma(PTC)underwent 131I therapy in the Department of Nuclear Medicine,Tianjin Medical University General Hospital from January 2015 to December 2020 were enrolled.Chi-square test and Mann-Whitney U test were used to compare the differences of clinicopathological features and 131I therapy,therapeutic response between two groups.The incomplete response(IR)rate curves of the two groups were plotted by Kaplan-Meier analysis.Results The proportion of patients with multifocal,involvement of bilateral thyroid lobes in PTMC group were higher than those in non-PTMC group,and the proportion of patients with extra-thyroid extension,T4,N1b,stimulated thyroglobulin(sTg)>10 μg/L,and high risk stratified were lower than those in non-PTMC group(P<0.05).Most patients in PTMC group received remnant ablation for the first time,while more patients in non-PTMC group received adjuvant therapy and therapy for known disease(P<0.05).There was no statistically significant difference in 131I therapeutic response,the rates of excellent response(ER)and IR in two groups,and the differences in curves of IR rate between the two groups were also no statistically significance(P>0.05).Conclusions PTMC has a certain degree of invasiveness.As long as the patients were comprehensively evaluated and the standard 131I therapy was adopted,the treatment outcomes of patients with PTMC and non-PTMC were roughly the same.Therefore,the clinical value of the definition of PTMC is extremely limited in the formulation of 131I therapeutic dose regimens.关键词
甲状腺肿瘤/甲状腺乳头状癌/放射疗法/碘放射性同位素/治疗转归Key words
Thyroid tumor/Papillary thyroid carcinoma/Radiotherapy/Iodine radioisotope/Treatment outcome分类
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蔡晓雨,张瑞国,胡玉敬,王任飞,边艳珠..乳头状甲状腺微小癌不宜作为术后131I治疗的决策依据[J].外科理论与实践,2023,28(6):529-535,7.
