医药导报2024，Vol.43Issue(3)：374-379,6.DOI:10.3870/j.issn.1004-0781.2024.03.007
老年肝癌患者系统治疗策略
Systemic Treatment Strategies for Elderly Patients with Hepatocellular Carcinoma
摘要
Abstract
Senescence is the major risk factor that promotes development of different stages of chronic liver diseases and is closely related to occurrence of hepatocellular carcinoma.Significant differences consist in clinicopathological features and tumor microenvironment between elderly and young patients with hepatocellular carcinoma.With rapid development of systemic therapy,immune checkpoint inhibitors combined with targeted therapy have greatly improved the prognosis of patients with advanced hepa-tocellular carcinoma.The selection of treatment decisions for elderly patients with hepatocellular carcinoma requires to consider u-nique age-related issues.Adequate communication and necessary evaluation should be carried out before making decisions.Elderly patients with hepatocellular carcinoma are speculated to benefit from combination immunotherapy based on age subgroup analysis of large clinical studies.However,data of effects and security obtained from clinical trials has certain limitations when being ap-plied in elderly populations of real world.The optimal therapeutic strategies for elderly patients with hepatocellular carcinoma still remain to be further explored in large-scale prospective clinical studies.关键词
肝癌患者/老年/系统治疗策略/免疫检查点抑制剂Key words
Hepatocellular carcinoma patients/elderly/Systematic treatment strategies/Immune checkpoint inhibitors分类
医药卫生引用本文复制引用
孙伊婷,滕赞,刘云鹏,曲秀娟..老年肝癌患者系统治疗策略[J].医药导报,2024,43(3):374-379,6.基金项目
沈阳市恶性肿瘤综合治疗临床医学研究中心(2021年沈阳市科技创新平台). （2021年沈阳市科技创新平台）
