医药导报2024，Vol.43Issue(3)：414-418,5.DOI:10.3870/j.issn.1004-0781.2024.03.015
血浆氧化三甲胺水平与心力衰竭相关性研究进展
Research Advance in the Relationship Between Plasma Trimethylamine Oxide Level and Heart Failure
王丽曼 1陈艳 1许丽丽 1周玉皆 2葛卫红 3徐航3
作者信息
- 1. 中国药科大学南京鼓楼医院药学部,南京 210008||中国药科大学基础医学与临床药学学院,南京 210009
- 2. 中国药科大学南京鼓楼医院呼吸与危重症医学科,南京 210008
- 3. 中国药科大学南京鼓楼医院药学部,南京 210008
- 折叠
摘要
Abstract
Intestinal microorganisms and their metabolites are involved in the pathogenesis and progression of various cardiovascular diseases,especially in the progression of heart failure.This paper mainly discussed the gut microbial metabolites trimethylamine oxide(TMAO)participated in the pathological process of heart failure,and application value of TMAO in heart failure patients.This paper introduced the change characteristics of intestinal flora and its metabolites in heart failure patients,illu-minated the TMAO-mediated inflammatory response,and the related signal pathways and mechanism of myocardial hypertrophy and heart failure.High levels of TMAO are associated with poor outcomes in patients with heart failure indicating a good predictive value for the prognosis of heart failure.Regulating TMAO levels through diet,probiotics and prebiotics,antibiotics,fecal transplan-tation,and other pathways is expected to be a potential treatment for heart failure.关键词
肠道菌群/氧化三甲胺/心力衰竭/治疗靶点Key words
Gut microbiota/Trimethylamine oxide/Heart failure/Therapeutic targets分类
医药卫生引用本文复制引用
王丽曼,陈艳,许丽丽,周玉皆,葛卫红,徐航..血浆氧化三甲胺水平与心力衰竭相关性研究进展[J].医药导报,2024,43(3):414-418,5.
