夹脊电针对急性脊髓损伤大鼠脊髓组织NOD样受体热蛋白结构域相关蛋白3介导的细胞焦亡的影响OA北大核心CSTPCD
Effect of electroacupuncture of"Jiaji"(EX-B2)on NOD-like receptor protein 3 mediated pyroptosis in spinal cord tissue of rats with acute spinal cord injury
目的:观察夹脊电针对脊髓损伤(SCI)大鼠运动功能、脊髓组织形态、脊髓组织NOD样受体热蛋白结构域相关蛋白3(NLRP3)及活化的半胱氨酸蛋白酶-1(cleaved Caspase-1)、焦孔素 D(GSDMD)-N表达的影响,探讨夹脊电针治疗SCI的作用机制.方法:SD大鼠随机分为假手术组、模型组、电针组、激动剂+电针组,每组分为3、7 d两个亚组,每个时间点6只大鼠.采用改良Allen's法制备急性SCI大鼠模型.电针组大鼠电针双侧胸(T)9…查看全部>>
Objective To observe the effect of electroacupuncture(EA)stimulation of"Jiaji"(EX-B2)on motor function,histomorphology,and expression of NOD-like receptor protein 3(NLRP3)and N-terminal domain of gasdermin D(GSDMD-N)in the spinal cord tissue of rats with spinal cord injury(SCI),so as to explore its mecha-nism underlying improvement of SCI.Methods Forty eight female SD rats were randomly divided into sham surgery(sham),SCI model(model),EA,and NLRP3 agonist(mo…查看全部>>
梅继林;杨志新;李晓宁
黑龙江中医药大学,哈尔滨 150040承德医学院,河北承德 067000黑龙江中医药大学附属第二医院,哈尔滨 150001
电针夹脊脊髓损伤NOD样受体热蛋白结构域相关蛋白3细胞焦亡小胶质细胞
ElectroacupunctureJiaji(EX-B2)Spinal cord injuryNLRP3PyroptosisMicroglia
《针刺研究》 2024 (2)
110-118,9
黑龙江省头雁团队项目基金(No.2019-9)黑龙江中医药大学校级科技创新研究平台项目(No.2018pt03)
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