亚精胺通过改善心脏线粒体能量代谢缓解压力超负荷小鼠心力衰竭OA北大核心CSTPCD
Spermidine alleviates pressure overload-induced heart failure in mice via improving cardiac mitochondrial energy metabolism
目的:探讨亚精胺(spermidine,SPD)对小鼠压力超负荷心肌肥大和心力衰竭的缓解作用及其机制.方法:(1)将8周龄的雄性C57BL/6J小鼠随机分为4组:假手术(sham)组、sham+SPD喂养组、主动脉弓缩窄(transverse aortic constriction,TAC)组和TAC+SPD组.TAC术后,sham+SPD组和TAC+SPD组小鼠经饮水喂养SPD(3 mmol/L);Western blot检测心肌组织沉默信息调…查看全部>>
AIM:To investigate the effect of spermidine(SPD)on pressure overload-induced cardiac hyper-trophy and heart failure model in mice and its underlying mechanisms.METHODS:(1)Eight-week-old male C57BL/6J mice were randomly divided into 4 groups:sham group,sham+SPD group,transverse aortic constriction(TAC)group,and TAC+SPD group.After TAC,the mice in sham+SPD group and TAC+SPD group were fed with 3 mmol/L SPD via drinking water,and the mice in other groups were f…查看全部>>
张晓亮;赵晓玲;耿静;胡朗;李妍
空军军医大学唐都医院心内科, 陕西 西安 710032中国人民解放军联勤保障部队第九四〇医院超声诊断科,甘肃 兰州 730050空军军医大学唐都医院心内科, 陕西 西安 710032空军军医大学唐都医院心内科, 陕西 西安 710032空军军医大学唐都医院心内科, 陕西 西安 710032
临床医学
亚精胺心肌肥大心力衰竭线粒体能量代谢沉默信息调节因子6过氧化物酶体增殖物激活受体γ辅激活因子1线粒体融合蛋白2
spermidinecardiac hypertrophyheart failuremitochondrial energy metabolismsilent infor-mation regulator 6eroxisome proliferator-activated receptor γ coactivator-1mitofusin 2
《中国病理生理杂志》 2024 (2)
193-203,11
国家自然科学基金资助项目(No.81770369No.82300443)
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