穿心莲内酯介导c-SKI抑制心肌成纤维细胞转分化和心肌纤维化OA北大核心CSTPCD
Andrgrapholide-mediated c-SKI inhibits myocardial fibroblast transdif-ferentiation and myocardial fibrosis
目的:探讨c-SKI(cellular Sloan-Kettering Institute)蛋白表达变化对穿心莲内酯(andrgrapholide,Andr)治疗小鼠心肌纤维化的影响.方法:将18只C57雄性小鼠随机分为control组、模型组[异丙肾上腺素(iso-prenaline,ISO)组]和ISO+Andr组,每组6只.ISO组和ISO+Andr组小鼠皮下注射ISO,control组注射生理盐水;ISO+Andr组小鼠给予Andr灌胃,…查看全部>>
AIM:To investigate the effect of cellular Sloan-Kettering Institute(c-SKI)protein expression on myocardial fibrosis in mice treated with andrgrapholide(Andr).METHODS:Male C57 mice were randomly divided into control group,model group[isoprenaline(ISO)group]and ISO+Andr group,with 6 mice per group.The mice in ISO and ISO+Andr groups were subcutaneously injected with ISO,while those in control group were injected with normal sa-line.The mice in ISO+Andr group w…查看全部>>
高敏;丁欢欢;郑丽华;王娟
新疆医科大学第五附属医院心内科,新疆 乌鲁木齐 830001新疆医科大学第五附属医院心内科,新疆 乌鲁木齐 830001新疆医科大学第五附属医院心内科,新疆 乌鲁木齐 830001新疆医科大学第五附属医院心内科,新疆 乌鲁木齐 830001
临床医学
穿心莲内酯心肌纤维化细胞外基质c-SKI蛋白转化生长因子β1
andrgrapholidemyocardial fibrosisextracellular matrixc-SKI proteintransforming growth factor-β1
《中国病理生理杂志》 2024 (2)
213-220,8
国家自然科学基金资助项目(No.81960052)
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