中国病理生理杂志2024，Vol.40Issue(2)：365-374,10.DOI:10.3969/j.issn.1000-4718.2024.02.021
铁自噬介导铁死亡机制和检测方法的研究进展
Progress in mechanism and detection methods of ferrinophagy-mediated ferroptosis
摘要
Abstract
Ferroptosis is an iron-dependent form of regulated cell death,which is distinct from apoptosis,ne-crosis,and pyroptosis.Recent studies have found that activators of ferroptosis,such as Erastin,can activate autophagy-re-lated proteins,induce the formation of autophagosomes,and ultimately release ferric ions to mediate ferroptosis.This pro-cess,called ferritinophagy,is initiated by the binding of an autophagic cargo receptor protein,nuclear receptor coactivator 4(NCOA4),to iron-laden ferritin.The transfer of NCOA4-ferritin to the lysosome by ferritinophagy results in the proteoly-sis of ferritin,and,in turn,the release of its iron content and lipid-reactive oxygen species(ROS)accumulation.Ferritin-ophagy has been closely associated with central nervous system disorders,circulatory system diseases,and cancer.Fur-thermore,the regulation mechanism of ferritinophagy is also a hot topic in the study of iron-dependent cell death process.With the in-depth study of ferritinophagy,great progress has been made in the study of key components of ferritinophagy as well as its molecular mechanisms and processes.However,a comprehensive summary of the methods for detecting ferritin-ophagy is still unclear.To further deepen the understanding of ferritinophagy and its detection methods,this review focus-es on the concept,characteristics,methods,and precautions during detection of ferritinophagy.This review provided ex-perimental reference for subsequent researchers and promoting the progress of research related to ferritinophagy.关键词
铁死亡/铁自噬/铁蛋白/NCOA4/铁离子Key words
ferroptosis/ferritinophagy/ferritin/NCOA4/ferric ion分类
医药卫生引用本文复制引用
郭婕,王玉龙,麦凤怡,杨文涛,梁靖蓉,舒俊翔,李陈广..铁自噬介导铁死亡机制和检测方法的研究进展[J].中国病理生理杂志,2024,40(2):365-374,10.基金项目
中国博士后基金面上项目(No.2021M702276) （No.2021M702276）
