中国全科医学2024，Vol.27Issue(12)：1417-1423,7.DOI:10.12114/j.issn.1007-9572.2023.0228
铁死亡:抑郁症治疗的新靶点
Ferroptosis:a New Target for the Treatment of Depressive Disorder
摘要
Abstract
As a common affective mental disorder,depressive disorder has currently become the second health burden worldwide,however,its pathogenesis remains to be further elucidated.The clinical treatment of depressive disorder primarily relies on western medicine.However,there is great clinical need for effective and rapid-onset antidepressants for the unsatisfactory effect,obvious treatment time-lag,and intolerable adverse reactions of current drug treatment.Ferroptosis is a novel form of cell death discovered in recent years,which has been found to be involved in the pathogenesis of numerous neurological disorders,including depressive disorder.Currently,some studies have shifted the focus of antidepressant treatment towards targeted inhibition of ferroptosis,and achieved positive outcomes.The present paper provides a comprehensive review of the involvement of ferroptosis in depressive disorder pathogenesis and its potential therapeutic implications,drawing on clinical and preclinical evidence that elucidates the underlying mechanisms linking depressive disorder with ferroptotic processes.关键词
抑郁症/铁死亡/铁沉积/线粒体/脂质过氧化作用/综述Key words
Depressive disorder/Ferroptosis/Iron overload/Mitochondria/Lipid peroxidation/Review分类
医药卫生引用本文复制引用
杜书琴,钱立锋,熊烈,史汉强,石彦波..铁死亡:抑郁症治疗的新靶点[J].中国全科医学,2024,27(12):1417-1423,7.基金项目
浙江省中医药卫生科技计划项目(2021ZB283) （2021ZB283）
浙江省卫生科技计划项目(2020PY029,2023KY1227) （2020PY029,2023KY1227）
嘉兴市科技局民生科技创新专项(2020AY30003) （2020AY30003）
浙江中医药大学附属医院科研专项重点项目(2022FSYYZZ22) （2022FSYYZZ22）
