中国全科医学2024，Vol.27Issue(12)：1487-1492,6.DOI:10.12114/j.issn.1007-9572.2023.0515
调中益气汤治疗老年气虚型慢传输便秘的疗效研究
Analysis of the Efficacy of Tiaozhong Yiqi Soup on Elderly Qi Deficiency Type Slow Transit Constipation
摘要
Abstract
Background Tiaozhong Yiqi Soup was first used to treat gastrointestinal diseases caused by spleen deficiency and dampness stagnation.Years of experience in treating slow transit constipation(STC)in the elderly through the addition or subtraction of this formula has been found can treat elderly slow transit constipation.Objective To evaluate the clinical effect of Tiaozhong Yiqi Soup on elderly Qi deficiency type STC and intestinal motility.Methods A total of 100 cases of Qi deficiency type STC patients were selected from the Proctology Department and the Prevention and Treatment Center of Traditional Chinese Medicine Hospital of Yinchuan City from May 2022 to April 2023,and randomly divided into the observation group of 50 cases and control group of 50 cases using a 1:1 randomized numerical table method.The observation group was orally treated with Tiaozhong Yiqi Soup decoction,the control group of 50 patients was orally treated with Prukapril Succinate Tablets,each group was treated for 4 weeks.The score of weekly Complete Spontaneous Bowel Movement(CSBM),traditional Chinese medicine(TCM)syndrome score,clinical symptom score,exclusion rates of markers at 48 and 72 hours before and after 4 weeks of treatment were recorded and compared,gastrointestinal hormone levels were detected and the occurrence of adverse reactions was observed.Follow up for 3 months to observe the recurrence of constipation in both groups of patients.Results After 4 weeks of treatment,the weekly CSBM score,TCM syndrome score,and clinical symptom score of the observation group were lower than those of the control group(P<0.05),and the exclusion rates of markers at 48 and 72 hours were significantly higher than those of the control group(P<0.05).The serum 5-HT,VIP,and SS of the observation group were lower than those of the control group,while the GAS higher than the control group,with statistical significant difference(P<0.05).The total clinical effective rate of the observation group was higher than that of the control group after 4 weeks of treatment(χ2=4.031,P=0.046).Following up for 3 months,the recurrence rate of the observation group was higher than that of the control group,and the difference was statistically significant(χ2=5.134,P=0.023).In the course of the study,2 cases in the observation group developed abdominal distension after taking Tiaozhong Yiqi Soup,while 4 cases in the control group developed dry mouth,nausea,dizziness,and other symptoms after taking Prukapril Succinate Tablets orally,all of which were not treated symptomatically,and the symptoms disappeared on their own after the termination of the trial.Conclusion Self formulated Tiaozhong Yiqi Soup can improve TCM syndrome,weekly CSBM,and clinical symptoms in elderly STC patients,regulate gastrointestinal neurohormone levels,promote gastrointestinal motility,with a low clinical recurrence rate,which is worthy of clinical promotion.关键词
便秘/慢传输便秘/老年人/气虚型/促胃肠动力药(中药)/胃肠激素类Key words
Constipation/Slow transmission constipation/Aged/Qi deficiency type/Prokinetic agents(TCD)/Gastrointestinal hormones分类
医药卫生引用本文复制引用
赵红波,吴晓晶,杨云,葛志明,范娴娴,赵岚,王宏伟..调中益气汤治疗老年气虚型慢传输便秘的疗效研究[J].中国全科医学,2024,27(12):1487-1492,6.基金项目
宁夏自然科学基金资助项目(2022AAC03749),宁夏回族自治区肛肠疾病(中西医结合)临床医学研究中心(2022LCZX0013) （2022AAC03749）
