中国体外循环杂志2023，Vol.21Issue(5)：277-281,5.DOI:10.13498/j.cnki.chin.j.ecc.2023.05.06
体外循环术中血液灌流降低主动脉夹层术后急性肾损伤发生风险
Hemoperfusion in the extracorporeal circulation reduces the risk of postoper-ative acute kidney injury in the aortic dissection operation
摘要
Abstract
Objective To explore the effect of hemoperfusion during extracorporeal circulation in acute aortic dissection operation on reducing the incidence of postoperative acute kidney injury(AKI).Methods Patients diagnosed with acute type A aortic dissection and treated with Sun's procedure from July 2022 to October 2022 at our hospital were included.Baseline charac-teristics,procedure data,clinical and biochemical data and prognostic outcomes of all the patients were retrospectively collected for analysis.Results A total of 57 patients were enrolled in the study,23 of which received hemoperfusion during extracorpore-al circulation.The incidence of AKI was significantly lower in the hemoperfusion group than in the non-hemoperfusion group(43.5%vs.85.3%,P=0.001),especially the grade 1 and 2 AKI(34.8%vs.61.8%,P=0.046).The maximum of creatinine[121(82,218)vs.174(112,220)umol/L,P=0.216]and cystatin C[1.63(1.34,2.85)vs.2.58(1.68,4.23)mg/L,P<0.05]at 7 days after the surgery were lower in the hemoperfusion group than those in the non-hemoperfusion group.There was also a decrease in the maximum value of procalcitonin at 3 days postoperatively in the hemoperfusion group compared with the non-hemoperfusion group[10.72(7.28,27.00)vs.6.50(2.60,11.0)ng/mL,P=0.011].The concentration of cold-inducible RNA-binding protein in se-rum did not show significant differences in the hemoperfusion group compared with the non-hemoperfusion group[987(664,1335)vs.993(741,1451)pg/mL,P=0.733].Conclusions Extracorporeal circulation combined with hemoperfusion in acute aor-tic dissection operation can reduce the risk of postoperative AKI,especially for grade 1 and 2 AKI.关键词
体外循环血/液灌流/急性肾损伤/主动脉夹层/心血管手术/冷诱导RNA结合蛋白Key words
Extracorporeal circulation/Hemoperfusion/Acute kidney injury/Aortic dissection/Cardiovasular surgery/Cold-inducible RNA binding protein引用本文复制引用
赵长缨,冯哲,牛佳兰,闫炀,刘锋锋,闫璐勤,郑幸龙..体外循环术中血液灌流降低主动脉夹层术后急性肾损伤发生风险[J].中国体外循环杂志,2023,21(5):277-281,5.基金项目
陕西省重点研发计划(2023-YBSF-482) （2023-YBSF-482）
西安交通大学第一附属医院临床研究课题面上项目(XJ-TU1AF2021CRF-029) （XJ-TU1AF2021CRF-029）
