中国药物经济学2023，Vol.18Issue(12)：34-37,4.DOI:10.12010/j.issn.1673-5846.2023.12.007
不同血药浓度的度洛西汀对功能性胃肠病患者的治疗效果
Therapeutic Effect of Duloxetine with Different Blood Concentrations on Functional Gastrointestinal Patients
摘要
Abstract
Objective To explore the therapeutic effect of duloxetine with different blood concentrations on functional gastrointestinal patients.Methods Seventy patients with functional gastrointestinal disease admitted to the Affiliated People's Hospital of Inner Mongolia Medical University from November 2021 to November 2022 were selected as the study objects and divided into group A(n=35)and group B(n=35)according to random number table method.Group A was given duloxetine 80 mg/d,group B was given duloxetine 60 mg/d.The clinical efficacy,blood concentration,anxiety,depression,motilin,gastrin-17 levels and TESS scores were compared between the two groups.Results The effective rate of group A was 92.59%,which was significantly higher than that of group B(66.67%)(P＜0.05).At the 1st,2nd and 6th week of treatment,the blood concentration of group A was higher than that of group B(P＜0.05);Before treatment,there was no significant difference in the scores of 9-item patient Health questionnaire Depression Scale(PHQ-9)and Generalized Anxiety Disorder Scale(GAD-7)between 2 groups(P＞0.05).After treatment,PHQ-9 and GAD-7 scores in group A were significantly lower than those in group B(P＜0.05);Before treatment,there was no significant difference in the levels of motilin and gastrin-17 between 2 groups(P＞0.05).After treatment,the level of motilin in group A was higher than that in group B,and the level of gastrin-17 was lower than that in group B,with statistical significance(P＜0.05).After treatment,the TESS scores of group A and group B were(3.15±0.52)points and(3.19±0.50)points,with no statistical significance(P＞0.05).Conclusion Duloxetine with a dose of 80 mg/d has more significant clinical efficacy in the treatment of functional gastrointestinal disease,and its blood concentration is higher than that of 60 mg/d,which can effectively improve patients'anxiety and depression,promote the recovery of gastrointestinal function,and has a high safety.关键词
度洛西汀/功能性胃肠病/血药浓度监测/临床疗效Key words
Duloxetine/Functional gastrointestinal disease/Blood drug concentration monitoring/Clinical effect分类
医药卫生引用本文复制引用
邬秀娟,支晓慧..不同血药浓度的度洛西汀对功能性胃肠病患者的治疗效果[J].中国药物经济学,2023,18(12):34-37,4.基金项目
2022年度自治区卫生健康科技计划项目(202202221) （202202221）
内蒙古医科大学联合项目(YKD2023LH029) （YKD2023LH029）
