胰高血糖素样肽-1受体激动剂司美格鲁肽和聚乙二醇洛塞那肽治疗肥胖症的研究进展OA
Advances in the Treatment of Obesity with the Glucagon-like Peptide-1 Receptor Agonists Semaglutide and Polyethylene Glycol Losenatide
全球肥胖患病率持续上升,对个人和公共卫生系统构成重大健康挑战.胰高血糖素样肽-1(GLP-1)激动剂司美格鲁肽和聚乙二醇洛塞那肽已被证明可以降低食欲、减少能量摄入并延迟胃排空,从而导致体重减轻.本文就GLP-1 受体激动剂司美格鲁肽和聚乙二醇洛塞那肽治疗肥胖症的作用机制、临床研究及安全性等内容进行综述.
The global prevalence of obesity continues to rise,posing a major health challenge for individuals and public health systems.The glucagon-like peptide-1(GLP-1)agonists Semaglutide and peglosenatide have been shown to reduce appetite,reduce energy intake and delay gastric emptying,leading to weight loss.This article reviews the mechanism of action,clinical studies and safety of GLP-1 receptor agonists Semaglutide and peglosenatide in the treatment of obesity.
傅劲超;任菁菁
浙江大学医学院附属第一医院全科医学科,杭州 310003浙江大学医学院附属第一医院全科医学科,杭州 310003
药学
肥胖胰高血糖素样肽-1受体激动剂司美格鲁肽聚乙二醇洛塞那肽
ObesityGlucagon-like peptide-1 receptor agonistSmaglutidePolyethylene glycol loxanatide
《中国药物经济学》 2023 (12)
116-121,6
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