广州医药2024，Vol.55Issue(2)：106-115,10.DOI:10.3969/j.issn.1000-8535.2024.02.001
转录组的重编写:腺苷到肌苷RNA碱基在肿瘤进展中的作用
Transcriptome reprogramming:The role of adenosine-to-inosine RNA bases in tumor progression
摘要
Abstract
Adenosine-to-inosine RNA editing(AIRE)is catalysed by adenosine deaminases acting on RNA(ADARs),which converts adenosine to inosine in nascent RNA.Since inosine is recognized as guanosine in post-transcriptional process,AIRE is functionally approximate to an A-to-G mutation and results in transcriptome recoding.With the continuous advancement of high-throughput sequencing technology,a large number of abnormal AIRE events have been found to exert different biological mechanisms such as amino acid changes,RNA splicing abnormalities and microRNA-mRNA redirection,which plays an important role in the development of human tumorigenesis.Most of AIRE sites are located in non-coding region,which brings challenges in analyzing their biological functions.This review aims to describe the biological mechanisms of AIRE and the relationship between AIRE sites and the development of different tumor types,providing ideas for the study of AIRE and tumors.关键词
腺苷到肌苷RNA编辑/癌症/生物学机制Key words
adenosine-to-inosine RNA editing/cancer/biological mechanism引用本文复制引用
唐人宇,杨瑞丰,伍健雄,邓培妍,杨磊..转录组的重编写:腺苷到肌苷RNA碱基在肿瘤进展中的作用[J].广州医药,2024,55(2):106-115,10.基金项目
国家自然科学基金面上项目(82373120) （82373120）
