血糖控制对2型糖尿病患者左、右心室心肌功能的影响OACSTPCD

This study investigated on left and right ventricular myocardial strain in patients with type 2 diabetes mellitus(T2DM),and the relationship between left and right ventricular dysfunction.A total of 100 patients with T2DM and normal left ventricular ejection fraction(LVEF)were divided into HbA1c＜7％group(n=54)and HbA1c≥7％group(n=46)according to HbA1c level.Forty healthy adult volunteers were selected as the control group.The data of conventional echocardiography and left ventricular global longitudinal strain(LVGLS),right ventricular global longitudinal strain(RVGLS)and right ventricular free wall longitudinal strain(RVFWLS)data were measured.The differences were compared among the groups.Multivariable linear regression analysis was performed for the associated between HbA1c and biventricular myocardial strain,and the correlation between left and right ventricular myocardial strain.LVGLS and RVGLS decreased gradually from the control group,HbA1c＜7％group to HbA1c≥7％group(all P＜0.05).Compared with the control group,RVFWLS was decreased in HbA1c＜7％group and HbA1c≥7％group(all P＜0.05).However,there was no significant difference between the latter two(P＞0.05).Multiple linear regression analysis showed that HbA1c was the independent determinants for LVGLS,RVGLS and RVFWLS in T2DM patients,and LVGLS was independently associated with RVGLS and RVFWLS.The left and right ventricular myocardial strain decreased,and there is association between them in T2DM patients with normal left ventricular ejection fraction.HbA1c is an independent determinant for left and right ventricular myocardial dysfunction,suggesting that hyperglycemia was independently associated with impaired of the biventricular myocardial at the same time,and suggests adverse interventricular interactions.