广州医药2024，Vol.55Issue(2)：146-150,202,6.DOI:10.3969/j.issn.1000-8535.2024.02.008
托烷司琼预处理配合丙泊酚全身麻醉对预防PONV的价值
The value of tropisetron preconditioning combined with propofol general anesthesia in preventing PONV
摘要
Abstract
Objective To observe the application value of tropisetron preconditioning combined with propofol general anesthesia in the prevention of postoperative nausea and vomiting(PONV).Methods This is a prospective cohort study.The patients were included from June 2021 to December 2022.The subjects of the study were 122 patients who received laparoscopy.All patients received general anesthesia assisted surgery containing propofol.The enrolled patients were divided into preconditioning group(61 cases)and conventional group(61 cases)by random number table.The conventional group was given routine antiemesis after surgery,and the preconditioning group was given tropisetron preconditioning.The incidence of PONV,improvement of vomiting symptoms,pain and sedation after anesthesia awakening,and occurrence of anesthesia related adverse reactions within 48 hours after surgery were compared between two groups of patients at different time points,including 6 hours,12 hours,24 hours,and 48 hours after surgery.Results Under different treatment regimens,the PONV incidence rates in the preconditioning group were 3.28%(2/61)after 6 hours,4.92%(3/61)after 12 hours,3.28%(2/61)after 24 hours,and 0.00%(0/61)after 48 hours.Compared with the conventional group[16.39%(10/61),18.03%(11/61),16.39%(10/61),and 13.11%(8/61)],the incidence rates were lower(P＜0.05).The preconditioning group had an Index of Nausea and Vomiting and Retching(INVR)score of(20.15±5.41)points after 6 hours,(17.66±4.42)points after 12 hours,(13.29±4.17)points after 24 hours,and(10.22±3.35)points after 48 hours.Compared with(23.32±5.13)points,(20.12±4.35)points,(16.33±4.24)points,and(12.75±3.06)points)of the preconditioning group,the INVR score at each time point was lower(P＜0.05).Under different treatment regimens,the VAS score of the preconditioning group after awakening was(4.04±1.06)points,and the Ramsay score was(3.11±0.25)points,which was similar to the conventional group[(3.87±0.25)points,(3.06±0.35)points](P＞0.05).Within 48 hours after surgery,the incidence of anesthesia related adverse reactions in the preconditioning group was 9.84%(6/61),which was similar to 8.20%(5/61)in the conventional group(P＞0.05).Conclusions Tropisetron preconditioning assisted laparoscopy under general anesthesia with propofol can effectively reduce the risk of PONV and improve the PONV related symptoms of patients.The combined use of this drug has no significant impact on the sedation and analgesia effects of anesthesia,and does not significantly increase the risk of postoperative anesthesia related adverse reactions,with high safety.关键词
腹腔镜手术/全身麻醉/托烷司琼/术后恶心呕吐/麻醉效果Key words
laparoscopy/general anesthesia/tropisetron/postoperative nausea and vomiting/anesthetic effect引用本文复制引用
周辉,徐振锋..托烷司琼预处理配合丙泊酚全身麻醉对预防PONV的价值[J].广州医药,2024,55(2):146-150,202,6.基金项目
河南省医学科技攻关项目(LHGJ2021004421) （LHGJ2021004421）
