海南医学院学报2024，Vol.30Issue(4)：297-303,7.DOI:10.13210/j.cnki.jhmu.20230605.004
补肾活血汤联合椎体成形术治疗OVCF:提高骨密度、改善生存质量的Meta分析
Meta-analysis of the efficacy and safety of Bushen Huoxue decoction in the treatment of Osteoporosis
摘要
Abstract
Objective:To systematically evaluate the long-term efficacy of Bushen Huoxue decoction combined with verte-broplasty(PVP or PKP)in the treatment of osteoporotic vertebral compression fractures(OVCF),in order to provide evidence-based reference for clinical application.Methods:To ensure the novelty and reliability of research data,all randomized controlled studies and clinical trials publishd between January 2017 and February 2023 at home and abroad on the treatment of OVCF with Bushen Huoxue Decoction combined with vertebroplasty in CNKI,Wanfang,Vip,PubMed,CBM,and Cochrane libraries were searched.Two researchers independently conducted literature screening and data extraction,evaluated the quality of randomized controlled trials one by one according to the Cochrane collaboration network standards,and conducted a meta statistical analysis us-ing RevMan5.3 for studies that met the inclusion criteria.Results:A total of 684 patients were included in seven randomized con-trolled trials,including 342 patients in the observation group and 342 patients in the control group,with a ratio of 1:1;The meta-analysis results showed that in the observation group,the overall effective rate[RR=1.30,95%CI(1.14,1.47),P<0.000 1],visual analog pain(VAS)score[SMD=1.19,95%CI(0.77,1.61),P<0.000 01],bone mineral density score[SMD=1.09,95%CI(0.15,2.04),P=0.02],COQOL score[SMD=0.99,95%CI(0.68,1.30),P<0.000 01],OPG score[SMD=0.48,95%CI(0.18,0.77),P=0.002]and the RANKL score[SMD=1.33,95%CI(1.00,1.65),P<0.000 01]were significantly su-perior to the control group,with statistically significant differences.There was no significant difference in the Oswestry Disability Index(ODI)score[SMD=0.27,95%CI(-0.03,0.57),P=0.08],Cobb score[SMD=1.52,95%CI(-1.05,4.09),P= 0.25],and vertebral height score[SMD=0.43,95%CI(-0.14,1.01),P=0.14].Conclusion:The results show that Bushen Huoxue decoction combined with vertebroplasty has significant advantages in improving bone mineral density and alleviating pain in patients after OVCF,which is significantly superior to using OVCF alone.关键词
补肾活血汤/椎体压缩骨折/疗效/Meta分析/随机对照试验Key words
Bushen Huoxue decoction/OVCF/Effect/Meta-analysis/RCT分类
医药卫生引用本文复制引用
李凯明,贾懿瑄,孙建峰,申杨勇,任桂菊,蔡同川,张清,孙树椿,崇辉..补肾活血汤联合椎体成形术治疗OVCF:提高骨密度、改善生存质量的Meta分析[J].海南医学院学报,2024,30(4):297-303,7.基金项目
This study was supported by National Natural Science Foundation Project of China(81904230,82205155) （81904230,82205155）
Capital Health Development Research Project(2018-2-4162)国家自然科学基金资助项目(81904230,82205155) （2018-2-4162）
首都卫生发展科研专项项目(2018-2-4162) （2018-2-4162）
