海南医学院学报2024，Vol.30Issue(4)：315-320,6.DOI:10.13210/j.cnki.jhmu.20230525.001
前交叉韧带损伤后形成骨性关节炎机制研究进展—基于生物学方向
Recent research progress from biological perspective on the mechanism of formation of osteoarthritis after anterior cruciate ligament injury
摘要
Abstract
The anterior cruciate ligament(ACL)mainly plays a role in stabilizing the knee joint by limiting the forward translation of tibial force and rotational force at the tibial joint,and if this ligament is damaged,it will cause joint pain,limited mo-bility,and knee instability etc.According to related studies,the incidence of post-traumatic osteoarthritis(PTOA)after ACL inju-ry is as high as 87%,although many studies have shown that patients with ACL injury are susceptible to PTOA,but the exact mechanism is currently unknown.This may be related to biological,structural,and mechanical factors caused by the ligament inju-ry.Previous studies have shown that elevated inflammatory mediators in the joint cavity following ACL injury can lead to chondro-cytes necrosis and degradation of the cartilage matrix.These potential biochemical mediators contribute to PTOA formation,and early intervention can reduce future episodes of PTOA.In recent years,many scholars have devoted themselves to studying the po-tential important factors and signaling pathways involved in the formation of osteoarthritis after ACL injury,and exploring its mo-lecular mechanism,which has led to great progress in this field.This paper mainly studies and discusses the mechanism of osteoar-thritis formation after ACL injury from the biological perspective.关键词
前交叉韧带损伤/生物学/骨性关节炎Key words
Anterior cruciate ligament injury/Biology/Osteoarthritis分类
医药卫生引用本文复制引用
周塏,杜秀藩,王广积..前交叉韧带损伤后形成骨性关节炎机制研究进展—基于生物学方向[J].海南医学院学报,2024,30(4):315-320,6.基金项目
This study was supported by Research Foundation of Hainan Medical University(HYPY2020014) （HYPY2020014）
National Natural Science Foundation of China(2021MSXM10)海南医学院科研培育基金项目(HYPY2020014) （2021MSXM10）
国家自然科学基金培育530工程面上项目(2021MSXM10) （2021MSXM10）
