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Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral

Hyun-Yi Kim Han-Sung Jung Victoria Cooley Eun-Jung Kim Shujin Li Jong-Min Lee Dina Sheyfer Wenjun Liu Ophir D.Klein Derk Joester

国际口腔科学杂志（英文版）2023，Vol.15Issue(4)：676-690,15.

国际口腔科学杂志（英文版）2023，Vol.15Issue(4)：676-690,15.DOI:10.1038/s41368-023-00257-w

Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral

Hyun-Yi Kim ¹Han-Sung Jung ²Victoria Cooley ³Eun-Jung Kim ²Shujin Li ²Jong-Min Lee ²Dina Sheyfer ⁴Wenjun Liu ⁴Ophir D.Klein ⁵Derk Joester⁶

作者信息

1. NGeneS Inc.,Ansan-si,Gyeonggi-do,Korea
2. Division in Anatomy and Developmental Biology,Department of Oral Biology,Oral Science Research Center,BK21 FOUR Project,Yonsei University College of Dentistry,Seoul,Korea
3. Department of Materials Science and Engineering,Northwestern University,Evanston,IL,USA||X-ray Science Division,Advanced Photon Source,Argonne National Laboratory,Lemont,IL,USA
4. X-ray Science Division,Advanced Photon Source,Argonne National Laboratory,Lemont,IL,USA
5. Department of Orofacial Sciences and Program in Craniofacial Biology,University of California,San Francisco,CA,USA||Department of Pediatrics,Cedars-Sinai Guerin Children's,Los Angeles,CA,USA
6. Department of Materials Science and Engineering,Northwestern University,Evanston,IL,USA
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摘要

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Hyun-Yi Kim,Han-Sung Jung,Victoria Cooley,Eun-Jung Kim,Shujin Li,Jong-Min Lee,Dina Sheyfer,Wenjun Liu,Ophir D.Klein,Derk Joester..Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral[J].国际口腔科学杂志（英文版）,2023,15(4):676-690,15.

基金项目

This work was supported by the National Research Foundation of Korea(NRF)Grant funded by the Korea Government(MSIP)(NRF-2022R1A2B5B03001627).This research used resources of the Advanced Photon Source,a U.S.Department of Energy(DOE)Office of Science User Facility operated for the DOE of Science by Argonne National Laboratory under Contract No.DE-AC02-06CH11357.This work made use of the following core facilities operated by Northwestern University:EPIC and SPID facilities of Northwestern University's NUANCE Center,which have received support from the SHyNE Resource(NSF ECCS-2025633),the IIN,and Northwestern's MRSEC program(NSF DMR-1720139) （NRF）

MatCI,supported by the MRSEC program(NSF DMR-1720139)at the Materials Research Center （NSF DMR-1720139）

and the Northwestern University George M.O'Brien Kidney Research Core Center(NU GoKidney),an NIH/NIDDK funded program(P30DK114857).V.C.,D.J.and O.D.K.were supported in part by NIH UH3 DE028872.V.C.was supported in part by the National Science Foundation through a Graduate Research Fellowship(DGE-1842165).The authors thank Dr.R.Free for contributing custom code for data analysis,Prof.S.R.Stock(Northwestern)for aid in analyzing pXRD data,and Prof.N.Blair(Northwestern)for assistance in acquiring μIR data. （NU GoKidney）

国际口腔科学杂志（英文版）

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