丹参饮合真武汤加减治疗慢性心力衰竭临床研究OA
Clinical Study on Salvia Beverage Combined with Modified True Warrior Decoction in the Treatment of Chronic Heart Failure
目的:观察丹参饮合真武汤治疗慢性心力衰竭的临床疗效及其对患者心功能的影响.方法:将96例慢性心力衰竭患者按照随机数字表法分为观察组和对照组,每组各48例.对照组给予常规西药治疗,观察组给予丹参饮合真武汤治疗.比较两组患者的临床疗效及治疗前后心功能[血浆N-末端原脑利钠肽(N-terminal-proB-ttype natriuretic peptide,NT-proBNP)、心肌营养素-1(cardiotrophin-1,CT-1)、可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)、心输出量(cardiac output,CO)、每搏量(stroke volume,SV)、左心室射血分数(leftventricula rejection fraction,LVEF)、左心室舒张峰值血流速度E峰与A峰的比值(E/A)]、中医证候积分、生活质量[明尼苏达心力衰竭生活质量量表(Minnesota heart failure quality of life scale,MLHFQ)评分、6 min 步行试验(6-minute walk test,6MWT)]变化情况.结果:两组患者治疗后 NT-proB-NP、CT-1、sICAM-1低于本组治疗前,CO、SV、LVEF、E/A高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P＜0.05).观察组有效率为93.75％,对照组有效率为79.17％,两组患者有效率比较,差异具有统计学意义(P＜0.05).两组患者治疗后胸闷、气喘、心悸、咳嗽、水肿的中医证候评分低于本组治疗前,且治疗后观察组低于对照组(P＜0.05).两组患者治疗后MLHFQ评分低于本组治疗前,6MWT高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P＜0.05).观察组不良反应发生率低于对照组,差异具有统计学意义(P＜0.05).结论:丹参饮合真武汤能有效提高慢性心力衰竭患者的临床疗效,改善心功能水平,提高患者生活质量.
Objective:To observe the clinical efficacy of Salvia Beverage combined with Modified True Warrior Decoction on patients with chronic heart failure and its effect on cardiac function.Methods:A total of 96 patients with chronic heart failure were divided into the observation group and the control group according to the random number table method,with 48 cases in each group.The control group was given conventional Western medicine treatment,while the observation group was given Salvia Beverage combined with Modified True Warrior Decoction.The clinical efficacy and the changes in cardiac function[including plasma N-terminal-pro B-type natriuretic pep-tide(NT-proBNP),cardiotrophin-1(CT-1),soluble intercellular adhesion molecule-1(sICAM-1),cardiac output(CO),stroke vol-ume(SV),left ventricular ejection fraction(LVEF),left ventricular diastolic peak blood flow velocity E peak to A peak ratio(E/A)],TCM syndrome scores,quality of life[including Minnesota heart failure quality of life scale(MLHFQ)score and 6-min walk test(6MWT)]before and after treatment were compared between the two groups.Results:After treatment,NT-proBNP,CT-1,sICAM-1 in the two groups were lower than those before treatment,while CO,SV,LVEF,E/A were higher than those before treatment,and all the differences between the two groups were statistically significant(P＜0.05).The effective rate of the observation group was 93.75％,and that of the control group was 79.17,and the difference was statistically significant(P＜0.05).After treatment,the TCM syndrome scores,such as chest tightness,asthma,palpitation,cough,and edema in the two groups were all lower than those before treatment,and the observation group's above scores were lower than those of the control group(P＜0.05);The MLHFQ score of the two groups was lower than that before treatment,while the 6MWT score was higher than that before treatment,and all the differences between the two groups were statistically significant(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference between the two groups was statistically significant(P＜0.05).Conclusion:Salvia Beverage combined with Modified True Warrior Decoction can effectively improve the clinical efficacy of patients with chronic heart failure,enhance the lev-el of cardiac function,and their quality of life.
董进军;王希山;李妍蓉;商李超
上海市奉贤区中医医院,上海 201499
中医学
慢性心力衰竭丹参饮真武汤中西医结合疗法
chronic heart failureSalvia BeverageTrue Warrior Decoctionintegrated traditional Chinese and Western medicine therapy
《河南中医》 2024 (001)
76-80 / 5
上海市奉贤区科委类科技发展基金项目(20201409);上海市奉贤区卫生健康委员会课题项目(2020JCCGZS-009)
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