四逆散合桃红四物汤治疗产后抑郁症临床研究OA
Clinical Study on the Treatment of Postpartum Depression with Frigid Extremities Powder Combined with Peach Kernel and Carthamus Four Substances Decoction
目的:观察四逆散合桃红四物汤治疗产后抑郁症的临床疗效.方法:将100例产后抑郁症患者按照随机数字表法分为中药组和西药组,每组各50例.西药组给予盐酸氟西汀片治疗,中药组给予四逆散合桃红四物汤治疗.比较两组患者的临床疗效、不良反应发生率及治疗前后中医证候积分、焦虑程度、抑郁程度、自我效能、人际关系、社会支持、生活质量评分变化情况.结果:两组患者治疗后精神不振、易怒善哭、嗳气太息、胸闷心悸、胸肋胀闷、失眠健忘等中医证候积分低于本组治疗前,且治疗后中药组低于西药组(P＜0.05).两组患者治疗后状态焦虑量表评分低于本组治疗前,且治疗后中药组低于西药组(P＜0.05).两组患者治疗后汉密尔顿抑郁量表评分低于治疗前,且治疗后中药组低于西药组(P＜0.05).中药组有效率为86.00％,高于西药组的60.00％(P＜0.05).两组患者治疗后自我效能、社会支持、生活质量评分均高于本组治疗前,人际关系评分低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P＜0.05).中药组不良反应发生率为4.00％,西药组不良反应发生率为20.00％,两组患者不良反应发生率比较,差异具有统计学意义(P＜0.05).结论:四逆散合桃红四物汤治疗产后抑郁症,可改善患者的临床症状,缓解焦虑、抑郁程度,提高临床疗效、人接交往能力及生活质量.
Objective:To observe the clinical efficacy of Frigid Extremities Powder combined with Peach Kernel and Carthamus Four Substances Decoction on postpartum depression.Methods:A total of 100 postpartum depression patients were randomly divided into the Chinese medicinal group and the Western medicine group according to the random number table method,with 50 cases in each group.The Western medicine group was treated with Fluoxetine Hydrochloride Tablets,while the Chinese medicinal group was treated with Frigid Extremities Powder combined with Peach Kernel and Carthamus Four Substances Decoction.Then the clinical efficacy,incidence of adverse reactions,and changes in TCM syndrome scores,anxiety level,depression level,self-efficacy,interpersonal relationships,so-cial support,and quality of life scores between two groups of patients before and after treatment.Result:After treatment,the scores and total scores of two groups of patients were lower than those before treatment,including low spirits,irritability,crying,belching,chest tightness,palpitations,chest rib distension,insomnia,and forgetfulness.Moreover,the Chinese medicinal group's above indexes were lower than those of the Western medicine group(P＜0.05).The state anxiety scale scores of the two groups of patients were lower than those before treatment,and the Chinese medicinal group was lower than the Western medicine group(P＜0.05).The Hamilton Depres-sion Scale scores of the two groups were lower than those before treatment,and the Chinese medicine group's score was lower than that of the Western medicine group(P＜0.05).The effective rate of the Chinese medicinal group was 86.00％,higher than that of the Western medicine group at 60.00％(P＜0.05).The self-efficacy,social support,and quality of life scores of the two groups were high-er than those before treatment,while the interpersonal relationship scores were lower than those before treatment.Moreover,there was a statistically significant difference between the two groups after treatment(P＜0.05).The incidence of adverse reactions in the Chinese medicinal group was 4.00％,while in the Western medicine group it was 20.00％.The difference in the incidence of adverse reactions between the two groups was statistically significant(P＜0.05).Conclusion:Frigid Extremities Powder combined with Peach Kernel and Carthamus Four Substances Decoction can improve the clinical symptoms of postpartum depression,alleviate anxiety and depression,en-hance clinical efficacy,interpersonal communication ability,and quality of life of patients with postpartum depression.
王子瑾;方婧;陈燕萍
中国福利会国际和平妇幼保健院,上海 200235
中医学
产后抑郁症四逆散桃红四物汤盐酸氟西汀
postpartum depressionFrigid Extremities Powder combined with Peach KernelCarthamus Four Substances DecoctionFlu-oxetine Hydrochloride
《河南中医》 2024 (001)
92-96 / 5
2019年度上海市闵行区自然科学研究项目(2019MHZ067)
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