中国实用神经疾病杂志2024，Vol.27Issue(3)：325-329,5.DOI:10.12083/SYSJ.231189
急性缺血性卒中入院后血尿酸水平对老年血管性痴呆的预测价值
Predictive value of serum uric acid level after admission for acute ischemic stroke in senile vascular dementia
摘要
Abstract
Objective To detect serum uric acid(SUA)levels in patients with acute ischemic stroke(AIS),and analyze the predictive value of SUA levels at different time points for vascular dementia(VD).Methods A total of 208 patients with AIS who were treated in Tangshan People's Hospital from January 2019 to August 2022 were enrolled,and 195 patients were followed up.According to whether VD was complicated by AIS after 3 months,the patients were divided into non-VD group(n=160)and VD group(n=35).The factors affecting AIS complicated with VD were analyzed by t test or χ2 test.The serum uric acid(UA)level in peripheral blood was detected at the time of admission,24 hours,7 days and 14 days of admission.Pearson correlation was used to analyze the correlation of blood UA in different periods.Logistic multivariate regression was used to analyze independent risk factors affecting AIS with VD,receiver operating curve(ROC)was used to eveluate the clinical value of serum uric acid levels in predicting AIS with VDin different periods.Results The history of stroke,atrial fibrillation,the size of dead lesion and NIHSS score on admission were significantly different between the two groups(P<0.05).Blood UA of VD group at 24 h((415.0±21.3)μmol/L),7 d((436.2±24.0)μmol/L)and 14 d((407.3±18.2)μ mol/L)were higher than non-VD group((398.4±26.8)μ mol/L,(372.1±20.7)μ mol/L,(358.1±14.7)μmol/L),there were significant differences between the two groups(P<0.05).History of stroke,atrial fibrillation,large infarct lesions and increased admission blood UA level were risk factors for AIS complicated by VD.The area under the curve of UA level at 7 days after admission to predict AIS complicated with VD was 0.935,which was higher than that at admission and 24 hours(0.763,0.786)(Z=4.526,4.084,P= 0.009,0.016).Conclusion Increased blood UA level is an independent risk factor for AIS complicated with VD,and blood UA level on the 7th day after admission has a high predictive value for AIS complicated with VD.关键词
急性缺血性脑卒中/血管性痴呆/血尿酸/预测价值Key words
Acute ischemic stroke/Vascular dementia/Serum uric acid/Predictive value分类
医药卫生引用本文复制引用
郝正玮,宋丽华,张秀清,孟宪静..急性缺血性卒中入院后血尿酸水平对老年血管性痴呆的预测价值[J].中国实用神经疾病杂志,2024,27(3):325-329,5.基金项目
河北省医学科学研究重点课题计划项目(编号:20191597) （编号:20191597）
