口腔颌面外科杂志2024，Vol.34Issue(1)：40-44,5.DOI:10.12439/kqhm.1005-4979.2024.01.006
cT1N0M0口腔鳞状细胞癌浸润深度对预测淋巴结转移和评价预后的影响
Effect of depth of invasion of cT1N0M0 OSCC on predicting lymph node metastasis and assessing prognosis
摘要
Abstract
Objective:To study the effect of the depth of invasion(DOI)on predicting lymph node metastasis and evaluating prognosis in patients with early oral squamous cell carcinoma(OSCC).Methods:Patients with early OSCC from January 2015 to December 2017 were enrolled and evaluated for pathological DOI and lymph node metastasis.The DOI cutoff value of lymph node metastasis in OSCC was predicted by the area under curve(AUC)of the receiver operating characteristic(ROC)curve.Moreover,the difference of lymph node metastasis rate and survival curve among different DOI groups was compared.Results:Ninety four early OSCC patients were included,with the median follow-up age of 66 and median follow-up time of 35.5 months.Pathological metastasis-positive node were observed in 18 patients with the average DOI of 6.09 mm;the average DOI of others was 3.61 mm(P<0.05).The area under the ROC curve was 0.86,and the optimal DOI cutoff value was 4.41 mm(sensitivity 78%;specificity 84%).When DOI>4.41 mm,lymph node metastasis rate was higher,that is 14.89%vs 4.25%(P<0.05)and the median survival was shorter(41.4 months vs 52.6 months;HR:1.80,95%CI:0.88～3.69,P=0.10).Conclusion:DOI in early OSCC showed positive correlation with the lymph node metastasis rate.However,the prognosis of these patients was not apparently worse,indicating the index may not be an independent predictor for both lymph node metastasis and prognosis in early OSCC patients.关键词
口腔鳞状细胞癌/浸润深度/淋巴结转移/预后Key words
oral squamous cell carcinoma/depth of invasion/lymph node metastasis/prognosis分类
医药卫生引用本文复制引用
楚晨,薛雨,闫周,邱建平,储伟明..cT1N0M0口腔鳞状细胞癌浸润深度对预测淋巴结转移和评价预后的影响[J].口腔颌面外科杂志,2024,34(1):40-44,5.基金项目
苏北人民医院院基金重点项目(SBKY21001) （SBKY21001）
苏北人民医院院基金优先项目(yzucms201905) （yzucms201905）
