口腔颌面外科杂志2024，Vol.34Issue(1)：63-66,4.DOI:10.12439/kqhm.1005-4979.2024.01.010
NLRP3炎性小体调控慢性牙周炎的研究进展
Research progress on NLRP3 inflammasome regulation of periodontitis
摘要
Abstract
Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome is a multi-protein complex that exists in the cytoplasm.It is involved in innate immune response and can regulate several inflammatory diseases.Periodontal pathogens can stimulate the secretion of several inflammatory cytokines via activating the NLRP3 inflammasome,resulting in periodontal inflammatory disease.This review provides a theoretical overview of periodontal pathogens that are reportedly capable of inflammasome activation,aiming to further exploration of the pathogenesis of chronic periodontitis(CP),which is essential for prevention and developing potential treatment approaches.关键词
慢性牙周炎/NLRP3炎性小体/白细胞介素-1β/红色复合体Key words
chronic periodontitis/NLRP3 inflammasome/interleukin-1β/red complex分类
医药卫生引用本文复制引用
李雪菁,苏俭生..NLRP3炎性小体调控慢性牙周炎的研究进展[J].口腔颌面外科杂志,2024,34(1):63-66,4.基金项目
国家自然科学基金(81873715、82170913) （81873715、82170913）
上海市科学技术委员会项目(18441902100、201409006200) （18441902100、201409006200）
