复方托吡卡胺对健康人视网膜微循环参数的影响OACSTPCD

Objective To investigate the influence of compound tropicamide on the quantitative evaluation of reti-nal microcirculation parameters measured by optical coherence tomography angiography(OCTA)among healthy subjects.Methods This was a cross sectional study.A total of 39 healthy subjects were enrolled.All subjects underwent OCTA measurement before and after the instillation of compound tropicamide.Various parameters including superficial capillary plexus vessel density(SVD),deep capillary plexus vessel density(DVD),foveal avascular zone(FAZ)area,FAZ area,the vessel density within a 300 μm wide ring surrounding the FAZ(FD-300),FAZ perimeter(PERIM),circularity Idex(CI)and radial peripapillary capillaries vessel density were obtained.Paired sample t-test was used to compare the differ-ences of OCTA parameters before and after mydriasis.Results A total of 39 healthy subjects were included in this study,including 25 male subjects and 14 female subjects,aged from 20 to 35 years old with an average age of(26.21±1.47)years old.The results of OCTA examination showed that there was no significant difference in macular SVD、DVD、FAZ area、FD-300、PERIM、CI and mean vessel density of optic disc before and after mydriasis in healthy subjects(P>0.05).Conclusions Compound tropicamide had no significant effect on macular SVD,DVD,FAZ area,FD-300,PERIM,CI and mean vessel density of optic disc among healthy subjects.