摘要
Abstract
Objective To analyze the 3-year prognosis of elderly lung cancer patients undergoing radical surgery and postoperative chemotherapy and explore its influencing factors.Methods A total of 98 elderly patients with lung cancer who underwent radical resection of lung cancer in Civil Aviation General Hospital from September 2019 to September 2020 were en-rolled as the research subjects.All patients were followed up for 3 years after surgery and their survival was recorded during the follow-up period.Their clinical data were collected.Multivariate Cox regression model was used to analyze the risk factors af-fecting the 3-year prognosis of elderly patients with lung cancer after postoperative chemotherapy.Results Among 98 lung cancer patients,51 ones(52.04% )experienced recurrence and metastasis,including local recurrence in 18 ones and distant metastasis in 33 ones.The main metastasis sites were lung,brain,bone and pleura.The median disease-free survival(DFS)was35.3 months,and the3-year DFS rate was47.96% (47/98).The results of univariate analysis showed that the 3-year DFS rate after surgery was related to tumor histological type,pathological stage,degree of differentiation,postoperative chem-otherapy cycle,as well as the levels of serum carcinoembryonic antigen(CEA),neuron specific enolase(NSE),squamous cell carcinoma antigen(SCC),carbohydrate antigen 125(CA125),and cytokeratin 19 fragment(CYFRA21-1)at recurrence(P＜0.05).The results of multivariate Cox regression analysis showed that pathological stage Ⅱ/Ⅲ,chemotherapy cycle＜3,CEA≥5.0 mg/dL,NSE≥17.0 ng/mL,SCC≥1.5 μg/L,CA125≥35 U/mL,CYFRA21-1≥3.5 ng/mL at recurrence were risk factors for the 3-year prognosis of elderly lung cancer patients undergoing radical surgery and postoperative chemotherapy(P＜0.05).Conclusion The 3-year DFS rate is 47.96% in elderly patients with lung cancer undergoing radical surgery and postoperative chemotherapy.Pathological staging Ⅱ/Ⅲ,chemotherapy cycle＜3,CEA≥5.0 mg/dL,NSE≥17.0 ng/mL,SCC≥1.5 μg/L,CA125≥35 U/mL,CYFRA21-1≥3.5 ng/mL at recurrence may be risk factors for the 3-year prognosis of elderly lung cancer patients undergoing radical surgery and postoperative chemotherapy.关键词
老年/肺癌/根治性手术/术后辅助化疗/预后/影响因素Key words
elderly/lung cancer/radical resection/postoperative adjuvant chemotherapy/prognosis/influencing factor
