老年医学与保健2024，Vol.30Issue(1)：179-184,6.
高尿酸血症肾皮质损伤后的肾脏超声变化
Renal ultrasound changes after renal cortex injury in hyperuricemia
摘要
Abstract
Objective To explore the ultrasound changes of renal cortex injury in hyperuricemia(HUA).Methods A total of 15 male SD rats were randomly divided into 3 groups(n =5 in each group),including normal group(Cont group),model group(HUA group)and febuxostat treatment group(HUA+Feb group,Feb 3 mg/kg·d).All rats were free to drink water and fed with regular feed.The rats in the HUA group were induced into models by gavage of oxazine acid(OA,750 mg/kg·d)for 8 weeks.The rats in the HUA+Feb group were given febuxostat by gavage for 4 weeks starting from the 5th week.After 8 weeks,the levels of serum urea nitrogen(BUN),blood creatinine(Scr)and blood uric acid(Sua)were detected.The activity of sodium-potassium ATPase(NKA)and the expression of NKA-α1 subunit protein in rat renal cortex were determined.The renal structure and cortical echogenicity were observed by ultrasound.The kidney/spleen echo-intensity ratio(K/S)was calculated.In addition,normal control subjects(n =44)and HUA patients(n =46)who received kidney ul-trasound examination in Huadong Hospital Affiliated to Fudan University were clinically recruited.Their basic clinical informa-tion was collected and compared.Results The results of animal experiments showed that compared with the Cont group,Sua level of the HUA group increased(P＜0.05),while NKA activity decreased(P＜0.05).Compared with the HUA group,Sua level of the HUA+Feb group decreased(P＜0.05),NKA activity and NKA-α1 protein expression increased(P＜0.05).The ultrasound results showed that the renal cortical echogenicity of the HUA group was higher than that of the Cont group(P＜0.05).After 4 weeks of treatment with febuxostat,the renal cortical echogenicity of the HUA+Feb group significantly improved(P＜0.05),and the K/S ratio was lower than that of the HUA group(P＜0.05).There were no significant differ-ences in renal length,width and renal parenchymal thickness among all groups(P＞0.05).The clinical data showed that HUA patients exhibited enhanced renal cortical echogenicity,increased crystallization and unclear structure,some of which were ac-companied by the formation of multiple small cystic lesions.Conclusion Early renal injury caused by HUA is accompanied by increased cortical echogenicity.Therefore,ultrasound may be used as a non-invasive imaging tool to evaluate renal injury caused by early HUA.关键词
高尿酸血症(HUA)/钠钾ATP酶(NKA)/超声Key words
hyperuricemia/sodium-potassium ATPase/ultrasound引用本文复制引用
吴德评,肖婧,刁雪红,张德先,夏依旦·米吉提,徐颖,管昊晨,郑玉琪,周璕,叶志斌..高尿酸血症肾皮质损伤后的肾脏超声变化[J].老年医学与保健,2024,30(1):179-184,6.基金项目
上海市科学技术委员会"科技创新行动计划"医学创新研究专项项目—面上项目(21Y11904000) （21Y11904000）
