临床眼科杂志2024，Vol.32Issue(1)：1-6,6.DOI:10.3969/j.issn.1006-8422.2024.01.001
多次玻璃体腔注射抗血管内皮生长药物对黄斑水肿患者角膜生物力学的作用
Effects of repeated intravitreal injections of anti-VEGF drugs on corneal biomechanics in patients with macular edema
祁媛媛 1宁吉良 2牟亚男 2袁琳慧 1张立军1
作者信息
- 1. 116033 大连医科大学附属 大连市第三人民医院眼科 辽宁省角膜与眼表疾病重点实验室 辽宁省眼视光工程技术研究中心眼科||116044 大连医科大学
- 2. 116033 大连医科大学附属 大连市第三人民医院眼科 辽宁省角膜与眼表疾病重点实验室 辽宁省眼视光工程技术研究中心眼科
- 折叠
摘要
Abstract
Objective To observe the effect of repeated intravitreal injections of anti-vascular endothelial growth factor(anti-VEGF)on corneal biomechanics.Methods A retrospective case series study.A total of 64 patients were treated with intravitreal injection of anti-VEGF.There were 19 cases of neovascularage-related macular degeneration(nAMD),20 cases of diabetic macular edema(DME)and 25 cases of retinal vein occlusion(RVO).29 cases were treated with Aflibercept(2 mg/0.05 ml)and 35 cases withRanibizumab(0.5 mg/0.05 ml).A total of 64 patients were treated with three consecutive in-jections,10 patients were treated with four consecutive injections.Corneal resistance factor(CRF),corneal hysteresis(CH),corneal compensation intraocular pressure(IOPcc),reproducible simulated goldmann intraocular pressure(IOPg)were collected.The changes of all the above indexes were compared after multiple intravitreal injections of two different drugs(Ranibizumab,Aflibercept)and in three different diseases(nAMD,DME,RVO).Results(1)There was no significant difference in corneal biomechanics at each time point after surgery of Ranibizumab or Aflibercept.(2)The number of injections had no significant correlation with the changes of corneal biomechanics.(3)There were no significant differences in corneal biomechanics at baseline among patients with three different diseases.(4)After 3 injections,the CH in DME group was higher than that in RVO and nAMD groups,and with significant differences.Conclusions The CH of DME group was significantly higher than that of RVO group and nAMD group after multiple intravitreal injections of anti-VEGF drugs.In patients with DME,multiple intravitreal injections of anti-VEGF drugs have effects on corneal biomechanics.关键词
血抗血管内皮生长因子/角膜生物力学/阿柏西普/雷株单抗Key words
Anti-vascular endothelial growth factor/Corneal biomechanics/Ranibizumab/Aflibercept分类
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祁媛媛,宁吉良,牟亚男,袁琳慧,张立军..多次玻璃体腔注射抗血管内皮生长药物对黄斑水肿患者角膜生物力学的作用[J].临床眼科杂志,2024,32(1):1-6,6.
