农药学学报2024，Vol.26Issue(1)：44-51,8.DOI:10.16801/j.issn.1008-7303.2023.0095
N-苯基八元氧桥环新烟碱化合物的合成及其增效活性
Synthesis and synergistic activity of N-phenyl-eight-membered oxabridged neonicotinoid analogues
摘要
Abstract
Insecticide synergists are key components to improve insecticidal efficacy and reduce resistance.In this work,further derivation of the eight-membered oxabridged structure with specific synergistic effect was conducted,fifteen novel N-phenyl-eight-membered oxabridged neonicotinoid derivatives were designed and synthesized,the mortality of the target compounds combined with imidacloprid against Aphis craccivora was tested.The results indicated that most of the target compounds increased the toxicity of imidacloprid against A.craccivora at the concentration of 1 mg/L.The non-substituted compound 4a and 4-CF3-substituted compound 4m exhibited the comparable synergistic effect,the synergism ratio was 3.44 and 3.58,respectively,which could be regarded as candidate compounds for further study.关键词
杀虫剂增效剂/八元氧桥环/新烟碱/吡虫啉/增效活性Key words
insecticide synergist/eight-membered oxabridged/neonicotinoid/imidacloprid/synergistic effect分类
化学化工引用本文复制引用
谭都,须志平,邵旭升,李忠..N-苯基八元氧桥环新烟碱化合物的合成及其增效活性[J].农药学学报,2024,26(1):44-51,8.基金项目
国家重点研究计划项目(2017YFD0200500). Supported by the National Key Research and Development Program of China(No.2017YFD0200500). （2017YFD0200500）
