农药学学报2024，Vol.26Issue(1)：52-60,9.DOI:10.16801/j.issn.1008-7303.2023.0094
新型酰基磺酰亚胺类化合物的合成及生物活性
Synthesis and bioactivity of novel sulfonazoline analogues
摘要
Abstract
A series of 20 novel acylsulfonimide derivatives 3a-3t were synthesized from phthalic anhydride,sulfonamide and butyl chloroformate by means of active substructure splicing.Their structures were confirmed by 1H NMR,13C NMR and high resolution mass spectrometry.The fungicidal and herbicidal activities of the target compounds were determined using the mycelial growth rate method and the stem and leaf spray method,respectively.The results of fungicidal activity showed that most of the compounds had good inhibitory effects against Sclerotinia sclerotiorum,Colletotrichum camalliae,Sclerotium rolfii and Phytophthora capsici at 50 mg/L.The inhibition rates of 3f,3n and 3q against S.sclerotiorum were 63.98%,79.56%and 77.83%,respectively,which were better than that of the commercial asulox(58.78%).The EC50 values of compound 3q against C.camalliae and S.sclerotiorum were 21.57 mg/L and 10.49 mg/L,respectively,which were better than asulox.The herbicidal activity results showed that,the fresh weight control effect of compound 3a against Echinochloa crus-galli was 52.48%at 150 mg/L,which was lower than asulox(71.68%).The novel compounds synthesized in this study displayed fungicidal activities,which can provide reference for the study of biological activities of novel acyl sulfonimide derivatives.关键词
酰基磺酰亚胺类化合物/氨基甲酸酯/抑菌活性/除草活性Key words
acylsulfonimides compounds/carbamate/fungicidal activity/herbicidal activity分类
化学化工引用本文复制引用
李瑞丽,徐志红,周静,杜晓英,朱祥..新型酰基磺酰亚胺类化合物的合成及生物活性[J].农药学学报,2024,26(1):52-60,9.基金项目
中国博士后科学基金(2022M710917) （2022M710917）
国家自然科学基金(32302417) （32302417）
湖北省自然科学基金(2023AFB287) （2023AFB287）
湖北省教育厅基金(B2021051). Supported by China Postdoctoral Science Foundation(No.2022M710917),National Natural Science Foundation of China(No.32302417),Hubei Provincial Natural Science Foundation(No.2023AFB287),and Hubei Provincial Department of Education Fund(No.B2021051). （B2021051）
