肿瘤预防与治疗2024，Vol.37Issue(2)：121-131,11.DOI:10.3969/j.issn.1674-0904.2024.02.004
基线18F-FDG PET/CT图像参数对非小细胞肺癌患者治疗后远处转移的预测价值研究
Predictive Value of Pre-treatment 18F-FDG PET/CT for Post-treatment Distant Metastasis in Patients with Non-Small Cell Lung Cancer
摘要
Abstract
Objective:This study aimed to investigate the pre-dictive value of pre-treatment 18F-FDG PET/CT for new distant me-tastases in patients with non-small cell lung cancer(NSCLC),and to provide a reference for the clinical treatment and follow-up pattern of NSCLC patients.Methods:The data from 118 patients with pathologically confirmed NSCLC who underwent 18F-FDG PET/CT at Sichuan Cancer Hospital from April 2015 to July 2021 were retrospectively analyzed,and none of these patients were found to have definite signs of distant metastasis at the time of initial diagnosis.PET metabolic parameters,CT imaging characteristics,and clinical data were analyzed using unifactorial and multifacto-rial COX regression to determine the factors predicting distant metastasis and calculate the optimal cut-off value.Results:During the two years of follow-up,a variety of distant metastases developed in 21 of 118 patients,including 8 brain metastases,7 bone metastases,4 adrenal metastases,4 lung metastases,1 liver metastases,1 pericardium metastases and 1 distant lymph node metastases.On univariate analysis,18F-FDG PET/CT parameters(SUVmax,MTV,TLG)and tumor maximum diameter(Dmax)showed significance in predicting distant metastasis(P<0.001),along with treatment,TNM stage,and presence of lymph node metastasis(P<0.05).However,multifactorial COX regression analysis showed that only maximum standardized uptake value(SUVmax)was an independent prognostic factor for new distant metastasis within two years after treatment in NSCLC patients(P = 0.018).The optimal cut-off value was 10.249(AUC = 0.811,P<0.001).Conclusion:Pre-treatment measurement of SUVmax using 18F-FDG PET/CT is an independent prognostic factor for predicting new distant metastases within a short time in NSCLC patients,which may provide valuable guidance for clinical treatment decisions and follow-up strategies.关键词
远处转移/PET/CT/非小细胞肺癌/FDGKey words
Distant metastasis/PET/CT/NSCLC/FDG分类
医药卫生引用本文复制引用
谭小飞,程祝忠,党军,叶真言,姚玉唐,寇莹,江骁,刘永莉,陈世容,游金辉..基线18F-FDG PET/CT图像参数对非小细胞肺癌患者治疗后远处转移的预测价值研究[J].肿瘤预防与治疗,2024,37(2):121-131,11.基金项目
This study was supported by grants from Science and Technology Department of Sichuan Province(No.2022YFS0068),Sichuan Medical and Health Care Promotion Institute(No.KY2022SJ0260)and Sichuan Cancer Hospital(No.YB2023022). 四川省科技计划项目(编号:2022YFS00 68) （No.2022YFS0068）
四川省医疗卫生与健康促进会科研项目(编号:KY 2022SJ0260) （编号:KY 2022SJ0260）
四川省肿瘤医院优秀青年基金(编号:YB 2023022) （编号:YB 2023022）
