老年医学与保健2024，Vol.30Issue(1)：18-22,5.
双向孟德尔随机化研究分析哮喘与肌少症的因果效应
Causal effect between asthma and sarcopenia:a bidirectional Mendelian randomization study
蔡虹 1裴晶祺 1唐琳妮 1朱迎钢1
作者信息
- 1. 复旦大学附属华东医院呼吸与危重症医学科,上海 200040
- 折叠
摘要
Abstract
Objective To explore the causal effect between asthma and sarcopenia by means of a Mendelian randomiza-tion(MR)study.Methods Two-sample MR method was used to evaluate the causal relationship between asthma dataset and three datasets associated with sarcopenia(low hand grip strength,limb muscle weight,and walking speed).The results of in-verse variance weighting method were used as the main indicators,and the MR-Egger regression,weighted median value,sim-ple mode-based estimation and mode-based weighted estimation were used as the references.The stepwise elimination method was used to test sensitivity,the Q test was used to test heterogeneity,and the MR pleiotropy function was used to test pleiotro-py.The reverse MR study was conducted to investigate the effect of sarcopenia on asthma.Results Asthma was associated with an increased probability of low hand grip strength(OR =1.703,95% CI:1.206-2.405,P =0.003),decreased limb muscle weight(OR = 0.733,95% CI:0.598-0.899,P =0.003),and decreased walking speed(OR = 0.930,95% CI:0.873-0.990,P =0.022).The stepwise elimination method confirmed that the causal effect of asthma on the 3 datasets of sar-copenia was stable.The reverse study did not find any promoting effect of sarcopenia on asthma.Conclusion Asthma pro-motes the occurrence and development of sarcopenia,and is a potential adverse factor for sarcopenia.关键词
哮喘/肌少症/孟德尔随机化研究/握力Key words
asthma/sarcopenia/Mendelian randomization study/grip strength引用本文复制引用
蔡虹,裴晶祺,唐琳妮,朱迎钢..双向孟德尔随机化研究分析哮喘与肌少症的因果效应[J].老年医学与保健,2024,30(1):18-22,5.
