实用休克杂志（中英文）2023，Vol.7Issue(6)：337-341,5.
体外膜肺氧合辅助治疗患者死亡危险因素分析
Analysis of death risk factors in patients with extracorporeal membrane oxygenation-assisted treatment
摘要
Abstract
Objective To analyze the risk factors patients undergoing extracorporeal membrane oxygenation(ECMO)auxiliary therapy within 7 days after weaning from the machine.Methods The clinical data of 112 patients with ECMO therapy were retrospectively analyzed and divided into death group(n=77)and survival group(n=35)based on survival within 7 days after weaning.The age,gender,body mass index,and logistic regression was used to analyze factors affecting the risk of death within 7 days after ECMO patients weaned from the past medical history.Then,vital signs and labo-ratory indicators,total days of hospitalization,ECMO mode and running time,APACHE Ⅱ score and other indicators were compared between these two groups through plotting ROC curve.Results APACHE Ⅱ score,admission with arrhythmia,arterial lactate(Lac),potassium ion(K+),pro-thrombin time(PT),operating time,ventilator application time before boarding,extracorporeal car-diopulmonary resuscitation(ECPR)There were significant differences in the clinical data between the death group and the survival group(P＜ 0.05).Binary logistic regression analysis showed that A-PACHE Ⅱ score,admission with arrhythmia,Lac and K+had a positive promoting effect on the risk of death.The ROC curve was drawn based on the results obtained by binary logistic regression,sug-gesting that the AUC value was 0.857(95％CI:0.788～0.926),with a sensitivity of 63.6％and a specificity of 97.1％.Conclusions APACHE Ⅱ score,admission with arrhythmia,Lac,K+,PT,ECMO running time,ventilator application time before boarding,and ECPR have certain value in pre-dicting death within 7 days after weaning of ECMO therapy patients.For patients with ECMO-assis-ted circulation who are admitted to hospital with arrhythmia,high APACHE Ⅱ score,high Lac,and high K+,the mortality rate within 7 days after weaning from the machine tends to increase.关键词
体外膜肺氧合/死亡/危险因素Key words
Extracorporeal membrane oxygenation/Death/Risk factor引用本文复制引用
王国营,刘维康,刘海雁,徐小伟,刘湘国,夏亚楠,边圆,徐峰..体外膜肺氧合辅助治疗患者死亡危险因素分析[J].实用休克杂志（中英文）,2023,7(6):337-341,5.基金项目
山东省重点研发计划(项目编号:2021ZLGX02) （项目编号:2021ZLGX02）
国家科技基础资源调查专项(项目编号:2018FY100600,2018FY100602) （项目编号:2018FY100600,2018FY100602）
国家重点研发计划(项目编号:2020YFC1512700,2020YFC1512705,2020YFC1512703,2022YFC0868600) （项目编号:2020YFC1512700,2020YFC1512705,2020YFC1512703,2022YFC0868600）
国家自然科学基金(项目编号:82070388,82172178,82172127,82072141,82272240,82072144) （项目编号:82070388,82172178,82172127,82072141,82272240,82072144）
泰山学者青年专家建设工程专项经费(项目编号:tsqn201812129,tsqn202103173,tsqn202211312,tsqn202211310,tsqn20161065) （项目编号:tsqn201812129,tsqn202103173,tsqn202211312,tsqn202211310,tsqn20161065）
山东大学青年交叉科学创新群体经费(项目编号:2020QNQT004) （项目编号:2020QNQT004）
山东大学临床研究中心经费支持(项目编号:2020SDUCRCA006,2020SD-UCRCB003,2020SDUCRCC018) （项目编号:2020SDUCRCA006,2020SD-UCRCB003,2020SDUCRCC018）
