实用肝脏病杂志2024，Vol.27Issue(2)：185-188,4.DOI:10.3969/j.issn.1672-5069.2024.02.007
非酒精性脂肪性肝病患者血清IL-1RA、CTRP13和CK-18水平变化及其临床意义探讨
Changes of serum IL-1RA,CTRP13 and CK-18 levels in patients with non-alcoholic fatty liver diseases
摘要
Abstract
Objective The aim of this study was to explore the clinical implications of serum interleukin-1 receptor antagonist(IL-1RA),complement C1q tumor necrosis factor related protein 13(CTRP13)and cytokeratin 18(CK-18)levels in patients with non-alcoholic fatty liver diseases(NAFLD).Methods 67 patients with NAFLD and 55 healthy individuals at physical examination were enrolled in our hospital between January 2021 and January 2023,and all patients received liver biopsies for hepatic steatosis classification.Serum IL-1RA,CTRP13 and CK-18 levels were detected by ELISA,and the risk factors for severe liver steatosis was determined by multivariate Logistic regression analysis.Results Serum IL-1RA and CTRP13 levels in patients with NAFLD were(328.6±54.3)pg/ml and(2634.2±397.5)pg/ml,both significantly lower than[(673.1±125.4)pg/ml and(3425.7±423.8)pg/ml,P＜0.05],while serum CK-18 level was(15.2±3.1)ng/ml,significantly higher than[(3.9±0.7)ng/ml,P＜0.05]in healthy persons;serum IL-1RA and CTRP13 levels in 17 patients with severe liver steatosis of F3 were(256.3±47.6)pg/ml and(2056.3±308.4)pg/ml,significantly lower than[(388.3±59.4)pg/ml and(3071.5±409.3)pg/ml,P＜0.05]in 29 patients with F1 steatosis or[(304.7±50.1)pg/ml and(2498.1±374.2)pg/ml,P＜0.05]in 21 patients with F2 steatosis,while serum CK-18 level was(23.4±4.7)ng/ml,significantly higher than[(8.1±1.3)ng/ml,P＜0.05]in patients with F1 or[(18.5±2.9)ng/ml,P＜0.05]in patients with F2 steatosis;the percentages of concomitant obesity,diabetes mellitus,hyperlipidemia,family history of metabolic syndromes,low serum IL-1RA and CTRP13,and high serum CK-18 levels in patients F3 steatosis were 70.6%,76.5%,88.2%,70.6%,35.3%,35.3%and 70.6%,significantly different compared to 38.0%,42.0%,40.0%,30.0%,92.0%,80.0%and 10.0%in 50 patients with F1/F2 steatosis(P＜0.05);the multivariate Logistic regression analysis showed that the obesity[OR(95%):2.0(1.1-3.6)],diabetes[OR(95%):2.1(1.1-4.1)],hyperlipidemia[OR(95%):1.6(1.0-2.6)],low serum IL-1RA[OR(95%):0.5(0.3-0.9)]and CTRP13[OR(95%):0.5(0.3-0.9)]and high serum CK-18[OR(95%):1.7(1.2-2.5)]were the risk factors for severe liver steatosis in patients with NAFLD(P＜0.05).Conclusion The abnormal changes of serum IL-1RA,CTRP13 and CK-18 levels in patients with NAFLD might help evaluate hepatic steatosis,and warrants further clinical investigation.关键词
非酒精性脂肪性肝病/白细胞介素-1受体拮抗剂/补体C1q肿瘤坏死因子相关蛋白13/细胞角蛋白18/临床意义Key words
Non-alcoholic fatty liver diseases/Interleukin-1 receptor antagonist/Complement C1q tumor necrosis factor related protein 13/Cytokeratin 18/Implications引用本文复制引用
高洋,张静,卢宣霖..非酒精性脂肪性肝病患者血清IL-1RA、CTRP13和CK-18水平变化及其临床意义探讨[J].实用肝脏病杂志,2024,27(2):185-188,4.基金项目
重庆市科技局科研基金资助项目(编号:2021KJ03401) （编号:2021KJ03401）
