实用医学杂志2024，Vol.40Issue(2)：242-247,6.DOI:10.3969/j.issn.1006-5725.2024.02.020
伊伐布雷定片联合左西孟旦在急性心肌梗死合并心力衰竭患者中的应用
Efficacy of ivabradine combined with levosimendan in patients with acute myocardial infarction compli-cated with heart failure
摘要
Abstract
Objective To observe the efficacy of ivabradine combined with levosimendan in patients with acute myocardial infarction complicated with heart failure.Methods A total of 78 patients with acute myocardial infarction complicated with heart failure admitted to the hospital from May 1,2020 to December 31,2022 were selected and divided into control group(n = 39)and study group(n = 39)by random number table method.In addition to basic treatment,the control group received levosimendan,and the study group ivabradine and levosi-mendan.The treatment period of both groups was 4 weeks.Compare two groups of patients'vital signs,clinical curative effect and heart function index,serological indexes,inflammatory factors and security.Results Compared with before treatment,the systolic blood pressure,diastolic blood pressure and heart rate of the two groups were decreased after treatment(P<0.05),and the systolic blood pressure,heart rate,diastolic blood pressure and heart rate of the study group were significantly decreased compared with the control group(P<0.05).Compared with the control group,the total effective rate of the study group was significantly higher(P<0.05).Compared with before treatment,the levels of CO and LVEF were increased(P<0.05),while the levels of LVEDV and LVESV were decreased(P<0.05).Compared with the control group,the levels of CO and LVEF in the study group were higher(P<0.05),and the levels of LVEDV and LVESV in the study group were lower(P<0.05).Compared with before treatment,the levels of cTnI,sST2 and NT-proBNP in both groups were decreased after treatment(P<0.05),and the serum levels of cTnI,sST2 and NT-proBNP in the study group were significantly decreased compared with the control group(P<0.05).Tumor necrosis factor α(TNF-α),myeloperoxidase(MPO)and highly sensitive C-reactive protein(hs-CRP)were all decreased after treatment in the two groups(P<0.05),and those in the study group were much lower(P<0.05)No difference between the incidence of adverse reactions to the total contrast the two groups(P>0.05).Conclusion Levosimendan combined with ivabadinehave a definite effect on patients with acute myocardial infarction complicated with heart failure for the improved cardiac function,reduced inflammation,regulated serum sST2,cTnI,and NT-proBNP level.It is also safe and reliable关键词
伊伐布雷定片/左西孟旦/急性心肌梗死/心力衰竭/临床疗效/安全性Key words
ivabradine/levosimendan/acute myocardial infarction/heart failure/clinical effect/security分类
医药卫生引用本文复制引用
文贤,曾显峰,苏蕊雅..伊伐布雷定片联合左西孟旦在急性心肌梗死合并心力衰竭患者中的应用[J].实用医学杂志,2024,40(2):242-247,6.基金项目
河南省科技攻关项目(编号:212102310779) （编号:212102310779）
