实用医学杂志2024，Vol.40Issue(4)：447-452,6.DOI:10.3969/j.issn.1006-5725.2024.04.002
柴胡-白芍配伍抗抑郁药理作用机制研究进展
Research progress on antidepressant pharmacological effects and mechanisms of Bupleuri Radix-Paeoniae Radix Alba herb-pair
摘要
Abstract
Depression is a frequently-seen mental disorder that profoundly affects the survival and quality of life of individuals.Present clinical medicine therapies for depression are not fully efficacious and novel therapeutic agents and targets remain necessary.Bupleuri Radix-Paeoniae Radix(BR-PRA),an essential and crucial compo-nent of traditional antidepressant compound,possesses the beneficial effect of lowering toxicity and amplifying the antidepressant effect when utilized in combination.The underlying mechanisms of these synergistic effects may involve the suppression of inflammation and oxidative stress,the regulation of monoamine neurotransmitters,brain-derived neurotrophic factors,the modulation of the hypothalamus-pituitary-adrenal axis,and the metabolism of various amino acids and energy.This article summarizes the synergistic effects and antidepressant pharmacological effects of BR-PRA herb-pair,thereby providing valuable insights into the potential advantages of this combination and its potential mechanisms of antidepressant action.关键词
柴胡-白芍/药对/抑郁/炎症反应/氧化应激Key words
Bupleuri Radix-Paeoniae Radix Alba/herb-pair/depression/inflammatory response,oxidative stress分类
医药卫生引用本文复制引用
蔡康林,张婧恺,冉亮弟,胡大军,冯知涛,黄慧莲..柴胡-白芍配伍抗抑郁药理作用机制研究进展[J].实用医学杂志,2024,40(4):447-452,6.基金项目
湖北省医学青年拔尖人才(编号:鄂卫通[2023]65) （编号:鄂卫通[2023]65）
