实用医学杂志2024，Vol.40Issue(4)：471-475,5.DOI:10.3969/j.issn.1006-5725.2024.04.006
新型冠状病毒感染者入院时血清降钙素原、白细胞介素-6和白细胞介素-8水平及其在患者预后中的意义
Serum levels of procalcitonin,interleukin-6 and interleukin-8 in patients with COVID-19 infection at admis-sion and their significance in patient prognosis
摘要
Abstract
Objective To analyze the predictive value of serum levels of procalcitonin(PCT)and cytokines on the prognosis of patients with COVID-19 at admission.Methods From November 2022 to February 2023,patients diagnosed with COVID-19 who were admitted to Beijing Chest Hospital were enrolled.Chemiluminescence was used to detect serum PCT levels,and flow microsphere array was used to detect serum cytokines IL-1β,IL-2,IL-4,IL-5,IL-6,IL-8,IL-10,IL-12p70,IL-17A,IL-17F,IL-22,TNF-α,TNF-β,IFN-γ level.ICU admission,mechanical ventilation and in-hospital death were defined as poor prognosis.After excluding patients with bacterial infection,the relationship between serum PCT and cytokine levels at admission and the prognosis of COVID-19 patients was analyzed.After excluding patients with bacterial infection,the relationship between serum PCT and cytokine levels at admission and the prognosis of COVID-19 patients was analyzed.Results A total of 176 patients with complete data were included,including 134 in the PCT-normal group and 42 in the PCT-elevated group,with a median age of 71.50 years and 71.59%males.Patients in the PCT elevated-group had significantly higher rates of ICU admission(38.41%vs.13.11%,P<0.05),mechanical ventilation(76.92%vs.24.59%,P<0.001)and in-hospital mortality(38.46%vs.6.56%,P<0.001)were significantly higher than those in the PCT-normal group.Serum levels of cytokines IL-6(7.40 pg/mL vs.4.78 pg/mL,P = 0.033 4)and IL-8(10.97 pg/mL vs.5.92 pg/mL,P<0.001)were significantly higher in patients with poor prognosis than in those with good prognosis.The area under the curve for PCT,IL-6,and IL-8 to predict poor prognosis in COVID-19 patients was 0.687,0.660,and 0.746,respectively;sensitivity was 52.78%,55.17%,and 72.41%,respectively;and specificity was 81.58%,74.19%,and 74.19%,respectively,as calculated from the ROC curve.When PCT,IL-6 and IL-8 jointly predict the prognosis of COVID-19 patients,the area under the curve is 0.764,the sensitivity is 70.00%,and the specificity is 80.00%.Conclusion Serum PCT and cytokines IL-6 and IL-8 could be used as predictive markers for poor prognosis in patients with COVID-19.关键词
新型冠状病毒感染/细胞因子/降钙素原/预后Key words
COVID-19 infection/cytokines/procalcitonin/prognosis分类
医药卫生引用本文复制引用
龙嗣博,施亦衡,时广利,赵艳,王桂荣,陈燕,张鑫桐,尹颜军,杨丽梅,郑迈克,王潮虹,孙晴,晏君..新型冠状病毒感染者入院时血清降钙素原、白细胞介素-6和白细胞介素-8水平及其在患者预后中的意义[J].实用医学杂志,2024,40(4):471-475,5.基金项目
北京市高层次公共卫生技术人才项目(编号:2022-3-040) （编号:2022-3-040）
北京市通州区科技计划项目(编号:KJ2023CX038) （编号:KJ2023CX038）
北京市通州区"两高"人才工程"领军人才"项目(编号:YH201917) （编号:YH201917）
