循环肿瘤DNA检测在人乳头瘤病毒相关性宫颈癌中的应用与展望OACSTPCD
Application and prospects of ctDNA detection in HPV associated cervical cancer
循环肿瘤DNA(circulating tumor DNA,ctDNA)是直接来源于肿瘤的无细胞状态DNA,其常携带全面的肿瘤基因信息;研究发现ctDNA的检测可在肿瘤的早期诊断、靶向治疗以及预测复发中发挥作用;人乳头瘤病毒(human papilloma virus,HPV)相关性妇科恶性肿瘤主要包括大部分宫颈癌、部分外阴癌及阴道癌,高危型HPV长期感染以及与细胞基因组的整合为这些癌肿重要的致病原因,研究发现利用ctDNA检测技术动态检测HPV-ctDNA的变化则可以为这些肿瘤的临床管理以及预后提供有价值的信息.因此,HPV-ctDNA有望成为HPV相关肿瘤的重要生物标志物.
Circulating tumor DNA(ctDNA)is a kind of cell-free DNA derived from tumors,which carries comprehensive tumor genetic information;Recent studies have found that ctDNA detection can play a role in the early diagnosis,targeted therapy,and prediction of recurrence in tumors.Human papillomavirus(HPV)-associated gynecological malignancies include most cervical cancer,some vulvar cancer,and vaginal cancer.High-risk HPV long-term infection and integration with cell genome are important causes of these cancers.Studies found that the use of ctDNA detection technology to dynamically monitor changes in HPV-ctDNA can provide valuable information for the clinical management and prognosis of these cancers.Thus,HPV-ctDNA is expected to become an biomarker for HPV-associated tumors.
江宝妮;张美琴;杨露;陈致远;韩娜娜
南方医科大学珠江医院妇产医学中心 (广州 510280)
临床医学
HPV-ctDNA人乳头瘤病毒宫颈癌妇科恶性肿瘤外阴癌阴道癌
HPV-ctDNAHPVcervical cancergynecologic malignancyvulva cancervagina cancer
《实用医学杂志》 2024 (002)
129-132 / 4
国家自然科学基金青年科学基金项目(编号:82001501)
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