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In vivo solid phase microextraction for therapeutic monitoring and pharmacometabolomic fingerprinting of lung during in vivo lung perfusion of FOLFOX

Nikita Looby Anna Roszkowska Miao Yu German Rios-Gomez Mauricio Pipkin Barbara Bojko Marcelo Cypel Janusz Pawliszyn

药物分析学报（英文）2023，Vol.13Issue(10)：1195-1204,10.
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药物分析学报（英文）2023，Vol.13Issue(10)：1195-1204,10.DOI:10.1016/j.jpha.2023.04.005

In vivo solid phase microextraction for therapeutic monitoring and pharmacometabolomic fingerprinting of lung during in vivo lung perfusion of FOLFOX

In vivo solid phase microextraction for therapeutic monitoring and pharmacometabolomic fingerprinting of lung during in vivo lung perfusion of FOLFOX

Nikita Looby 1Anna Roszkowska 2Miao Yu 1German Rios-Gomez 1Mauricio Pipkin 3Barbara Bojko 4Marcelo Cypel 3Janusz Pawliszyn1

作者信息

  • 1. Department of Chemistry,University of Waterloo,200 University Avenue West,Waterloo,ON,N2L 3G1,Canada
  • 2. Department of Chemistry,University of Waterloo,200 University Avenue West,Waterloo,ON,N2L 3G1,Canada||Department of Pharmaceutical Chemistry,Medical University of Gdansk,80-416,Gdansk,Poland
  • 3. Division of Thoracic Surgery,University Health Network,TGH,200 Elizabeth St,Toronto,ON,M5G 2C4,Canada
  • 4. Department of Pharmacodynamics and Molecular Pharmacology,Collegium Medicum in Bydgoszcz,Nicolaus Copernicus University in Torun,85-089,Bydgoszcz,Poland
  • 折叠

摘要

关键词

In vivo lung perfusion/Solid-phase microextraction/Chemotherapy/Metabolomics/Therapeutic drug monitoring

Key words

In vivo lung perfusion/Solid-phase microextraction/Chemotherapy/Metabolomics/Therapeutic drug monitoring

引用本文复制引用

Nikita Looby,Anna Roszkowska,Miao Yu,German Rios-Gomez,Mauricio Pipkin,Barbara Bojko,Marcelo Cypel,Janusz Pawliszyn..In vivo solid phase microextraction for therapeutic monitoring and pharmacometabolomic fingerprinting of lung during in vivo lung perfusion of FOLFOX[J].药物分析学报（英文）,2023,13(10):1195-1204,10.

基金项目

We would like to thank our collaborators at Millipore Sigma for providing us with the SPME fibers used in this work.We are grateful to the Canadian Institutes of Health Research(CIHR)-Natural Sciences and Engineering Research Council(NSERC)of the Canada Collaborative Health Research Projects program for their financial support(Grant No.:355935)and the Natural Sciences and Engineering Research Council of Canada Industrial Research Chair(IRC)program. （CIHR）

药物分析学报（英文）

OACSCD

2095-1779

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