临床医学工程2024，Vol.31Issue(2)：161-162,2.DOI:10.3969/j.issn.1674-4659.2024.02.0161
替雷利珠单抗联合阿帕替尼治疗晚期胃癌的效果观察
Observation on the Effect of Tirelizumab Combined with Apatinib in the Treatment of Advanced Gastric Cancer
闫睿 1闫桂芳2
作者信息
- 1. 济源市肿瘤医院肿瘤内科,河南济源 459000
- 2. 济源市第二人民医院内二科,河南济源 459000
- 折叠
摘要
Abstract
Objective To analyze the clinical effect of tirelizumab combined with apatinib in the treatment of advanced gastric cancer.Methods A total of 78 patients with advanced gastric cancer were randomly divided into two groups.The control group was treated with apatinib,and the observation group was treated with tirelizumab combined with apatinib.The disease control,tumor marker levels and adverse reactions were compared between the two groups.Results The DCR of the observation group was 84.62%,higher than 61.54%of the control group(P<0.05).After treatment,the levels of CA125 and CEA in the two groups were lower than those before treatment(P<0.05),and the levels of CA125 and CEA in the observation group were lower than those in the control group(P<0.05).No significant difference was found in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions Tirelizumab combined with apatinib in the treatment of advanced gastric cancer can significantly improve the disease control rate and reduce the levels of CA125 and CEA of patients,without significant increase of the occurrence of adverse reactions.关键词
替雷利珠单抗/阿帕替尼/晚期胃癌/肿瘤标志物/不良反应Key words
Tirelizumab/Apatinib/Advanced gastric cancer/Tumor marker/Adverse reaction分类
医药卫生引用本文复制引用
闫睿,闫桂芳..替雷利珠单抗联合阿帕替尼治疗晚期胃癌的效果观察[J].临床医学工程,2024,31(2):161-162,2.
