临床医学工程2024，Vol.31Issue(2)：197-198,2.DOI:10.3969/j.issn.1674-4659.2024.02.0197
达格列净对射血分数降低的心力衰竭患者心功能及血清NT-proBNP、cTnⅠ水平的影响
Impact of Dapagliflozin on Cardiac Function and Serum NT-proBNP and cTnⅠ Levels of Patients with Heart Failure with Reduced Ejection Fraction
龚庆平 1游倩 1王鸿权2
作者信息
- 1. 信阳市人民医院药学部,河南信阳 464000
- 2. 信阳市人民医院心内科,河南信阳 464000
- 折叠
摘要
Abstract
Objective To explore the impact of dapagliflozin on cardiac function and serum NT-proBNP and cTnⅠ levels of patients with heart failure with reduced ejection fraction(HFrEF).Methods A total of 120 patients with HFrEF were randomly divided into two groups.The control group was treated with standard heart failure drug treatment regimen,and the observation group was treated with dapagliflozin on the basis of the control group.The cardiac function,adverse events and levels of serum NT-proBNP and cTnⅠ were compared between the two groups.Results After treatment,LVEF of the observation group was higher than that of the control group,and LVESD,LVEDD,and levels of serum NT-proBNP and cTnⅠ were lower than those of the control group(P<0.05).The total incidence of adverse events of the observation group was 11.67％,lower than 30.00％of the control group(P<0.05).Conclusions Dapagliflozin can obviously improve the cardiac function of patients with HFrEF,reduce the levels of NT-proBNP and cTnⅠ,and reduce the occurrence of adverse events.关键词
心力衰竭/射血分数降低/达格列净/心功能/不良事件/NT-proBNP/cTnⅠKey words
Heart failure/Reduced ejection fraction/Dapagliflozin/Cardiac function/Adverse event/NT-proBNP/cTnⅠ分类
医药卫生引用本文复制引用
龚庆平,游倩,王鸿权..达格列净对射血分数降低的心力衰竭患者心功能及血清NT-proBNP、cTnⅠ水平的影响[J].临床医学工程,2024,31(2):197-198,2.
